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Item number: Cay10009798-25

EX-527 is an inhibitor of sirtuin 1 (SIRT1, IC50 = 0.098 µM). It is selective for SIRT1 over SIRT2, and SIRT3 (IC50s = 19.6 and 48.7 µM, respectively) and the cytochrome P450 (CYP) isoforms CYP3A4, CYP2D6, CYP2C9, CYP2C19, and CYP1A2 at 1 µM. EX-527 (50 µM) induces cell cycle arrest at the G1 phase in MCF-7...

Keywords:	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Application:	SIRT1 inhibitor
CAS	49843-98-3
MW:	248.7 D

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