5 products were found matching "Cay10009796-%25"!
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17(S)-HDHA
Item number: Cay10009799-25
17(S)-HDHA is a hydroxy fatty acid formed from docosahexaenoic acid (DHA, Cay-90310) by 15-lipoxygenase (15-LO) and is a precursor to 17(S)-resolvins. 17(S)-HDHA inhibits platelet 12-LO (IC50 = 0.4 µM). It inhibits TNF-alpha-induced expression of IL1B in a human glial cell line (IC50 = ~0.5 nM). 17(S)-HDHA (100 nM)...
| Keywords: | 17(S)-HDoHE, 17(S)-hydroxy Docosahexaenoic Acid, 17S-hydroxy-4Z,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid |
| Application: | Bioactive lipid assays |
| CAS | 92693-03-3 |
| MW: | 344.5 D |
From 94.00€
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(±)-EX-527
Item number: Cay10009798-25
EX-527 is an inhibitor of sirtuin 1 (SIRT1, IC50 = 0.098 µM). It is selective for SIRT1 over SIRT2, and SIRT3 (IC50s = 19.6 and 48.7 µM, respectively) and the cytochrome P450 (CYP) isoforms CYP3A4, CYP2D6, CYP2C9, CYP2C19, and CYP1A2 at 1 µM. EX-527 (50 µM) induces cell cycle arrest at the G1 phase in MCF-7...
| Keywords: | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide |
| Application: | SIRT1 inhibitor |
| CAS | 49843-98-3 |
| MW: | 248.7 D |
From 43.00€
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CAY10591
Item number: Cay10009797-25
Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been shown to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. Small molecule activators of SIRT1,...
| Keywords: | SIRT1 Activator 3, Sirtuin 1 Activator 3,... |
| Application: | SIRT1 assays |
| CAS | 839699-72-8 |
| MW: | 367.5 D |
From 86.00€
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(±)12(13)-EpOME-d4
Item number: Cay10009996-25
(±)12(13)-EpOME-d4 is intended for use as an internal standard for the quantification of 12(13)-EpOME by GC- or LC-MS. 12(13)-EpOME is an epoxide formed primarily via metabolism of linoleic acid (Cay-90150, Cay-90150.1, Cay-21909) by the cytochrome P450 (CYP) isoforms CYP2J2, CYP2C8, and CYP2C9, however, CYP1A1 can...
| Keywords: | (±)-Vernolic Acid-d4, (±)12,13-EODE-d4, Isoleukotoxin-d4, (±)12(13)epoxy-9Z-octadecenoic-9,10,12,13-d4 acid |
| Application: | Standard |
| MW: | 300.5 D |
From 149.00€
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Vigabatrin
Item number: Cay9000976-25
Vigabatrin is an irreversible GABA transaminase (GABA-T) inhibitor. It inhibits rat brain GABA-T when used at a concentration of 0.1 mM. Vigabatrin is selective for rat brain GABA-T over P. fluorescens GABA-T at 10 mM and is 100-fold selective over rat brain glutamic acid decarboxylase (GAD). Vigabatrin (1,500...
| Keywords: | gamma-Vinyl GABA, 4-amino-5-hexenoic acid |
| Application: | GABA analog |
| CAS | 68506-86-5 |
| MW: | 129.2 D |
From 60.00€
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