all-cis-1,2,3-Docosahexaenoyl glycerol is a polyunsaturated triacylglycerol that contains all-cis docosahexaenoic acid (DHA, Cay-90310) at the sn-1, sn-2, and sn-3 positions.Formal Name: (4Z,4'Z,4''Z,7Z,7'Z,7''Z,10Z,10'Z,10''Z,13Z,13'Z,13''Z,16Z,16'Z,16''Z,19Z,19'Z,19''Z)-4,7,10,13,16,19-docosahexaenoic acid,...

1,2,3-Trieicosapentaenoyl glycerol (EPA-TG) is a glycerol ester of eicosapentaenoic acid (Cay-90110, Cay-21908), which is an omega-3 fatty acid. An EPA-TG emulsion, administered i.v., lowers leukotriene B4 production by 40% in polymorphonuclear leukocytes from rabbits and reduces platelet aggregation. It suppresses...

Leptomycin B is a potent inhibitor of the nuclear export of proteins. It directly blocks the interaction of CRM1 (exportin 1) with nuclear export signals (NES), preventing the export of a broad range of proteins. Leptomycin B will also indirectly inhibit the export of mRNA from the nucleus by blocking the nuclear...

2-Arachidonoyl glycerol (2-AG) is an endogenous central cannabinoid (CB1) receptor agonist that is present at relatively high levels in the central nervous system. 2-AG is hydrolyzed by the enzyme monoacylglycerol lipase, terminating its biological activity, and metabolism by cyclooxygenase-2 and lipoxygenases has...

The effects of prostaglandin E2 (PGE2) are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4. GW 627368X is a potent and selective competitive antagonist of the EP4 receptor with additional human TP receptor affinity. In competition radioligand bioassays, GW 627368X had affinity for...