17 products were found matching "Cay10009749"!

Phosphatase and tensin homology on chromosome 10 (PTEN) functions as a key regulatory enzyme in many signal transduction pathways by dephosphorylating proteins and lipids such as AKT and phosphatidylinositol 3,4,5-trisphosphate (PIP3). PTEN interacts with many other proteins to regulate cell division and migration,...

17(S)-HDHA is a hydroxy fatty acid formed from docosahexaenoic acid (DHA, Cay-90310) by 15-lipoxygenase (15-LO) and is a precursor to 17(S)-resolvins. 17(S)-HDHA inhibits platelet 12-LO (IC50 = 0.4 µM). It inhibits TNF-alpha-induced expression of IL1B in a human glial cell line (IC50 = ~0.5 nM). 17(S)-HDHA (100 nM)...

The mechanism for the movement of cholesterol from intracellular sites to their ultimate cellular destination is an unresolved question of fundamental importance to cell biology and medicine. Thus, defining mechanisms of intracellular cholesterol transport and identifying the cellular factors involved are therefore...

Fatty acid binding protein 4 (FABP4) is a member of the intracellular lipid-binding protein (iLBP) family. It is composed of a beta-barrel, which forms the lipid-binding site, and two alpha-helices that form a lid on the beta-barrel. FABP4 is primarily expressed in adipocytes but has also been found in activated...

Ricinoleic acid is a naturally occurring 12-hydroxy fatty acid. It constitutes about 90% of the fatty acids in castor oil. Ricinoleic acid can serve as a substrate for the synthesis of conjugated linoleic acids. It is considered safe and non-toxic as a food constituent in humans, up to a daily intake of 2.5 grams...

Ionomycin is a calcium ionophore originally isolated from S. conglobatus. It induces intracellular calcium mobilization in X. laevis oocytes when used at a concentration of 5 µM. Ionomycin (5 µM) induces the formation of neutrophil extracellular traps (NETs) in isolated human neutrophils. Ionomycin in combination...

Formulation: A lyophilized powder. Origin: Plant/Triticum aestivum.

The NMDA receptor (NMDAR) plays an essential role in memory, neuronal development, and it has also been implicated in several disorders of the central nervous system including Alzheimer's disease, epilepsy, and ischemic neuronal death. The NR1 protein can form NMDA activated channels when expressed in Xenopus...

Formulation: 150 µl of unstimulated HeLa nuclear extract. Origin: Animal/Bovine.

6(S)-Lipoxin A4 (6(S)-LXA4) is an isomer of the trihydroxy fatty acid LXA4 (Cay-90410). It is formed from arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) through double lipoxygenase-catalyzed reactions initiated by either 5-lipoxygenase (5-LO) followed by 12- or 15-LO, with a leukotriene A4 (LTA4)...

AM630 binds selectively to cannabinoid 2 (CB2) over CB1 receptors with Ki values of 31.2 and 5,152 nM, respectively. AM630 acts as an inverse agonist at CB2 receptors, attenuating the antinociceptive effects of a number of cannabinoids, and as a weak partial agonist at CB1 receptors. It decreases proliferation and...

Methylhexanamine (hydrochloride) is a simple aliphatic amine that was once marketed as a nasal decongestant (Forthane) but is now sold as a bodybuilding supplement (Floradrene, Geranamine). It is also sold as a mild stimulant in the form of party pills and has been reported to cause cerebral hemorrhage in a case...