17 products were found matching "Cay10009734"!

1,2-Dipalmitoyl-sn-glycero-3-PC (1,2-DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications. It has been used in the formation of proteoliposomes for implantation of gamma-glutamyl transpeptidase into human...

Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of phosphatidylinositol at the 3 position to produce the second messengers phosphatidylinositol-3,4-bisphosphate (PtdIns-(3,4)-P2) and PtdIns-(3,4,5)-P3. Class 1 PI3Ks are composed of a p110 catalytic subunit, of which there are 4 isoforms...

Cyclooxygenase 2 (COX-2) is a bifunctional enzyme that exhibits both COX and peroxidase activities and catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins. The COX component converts arachidonic acid to the hydroperoxy endoperoxide prostaglandin G2 (PGG2, Cay-17010), and...

Glycogen synthase kinase 3beta (GSK3beta) is a serine/threonine protein kinase that has roles in numerous signaling pathways and cellular processes, including cell proliferation and survival, as well as neural development and plasticity. It is composed of an N-terminal beta-strand domain, a kinase domain, and a...

3(Z),6(Z),9(Z),12(Z),15(Z)-Octadecapentaenoic acid is a microalgal PUFA that has been found in G. kowalevskii. It has been used as a chemotaxonomic biomarker for microalgae and dinoflagellates.CAS Number: 51592-59-7. Synonyms: C18:5(3Z,6Z,9Z,12Z,15Z), C18:5 n-3, FA 18:5, all-cis-3,6,9,12,15-Octadecapentaenoic Acid....

Kifunensine was originally isolated from the actinomycete Kitasatosporia kifunensine No. 9482 and shown to be a weak inhibitor of aryl mannosidase. It has since been shown to be a potent and selective inhibitor of class I alpha-mannosidases and may serve as a key inhibitor of glycoprotein biosynthesis. Kifunensine...

1,2,3-Trieicosapentaenoyl glycerol (EPA-TG) is a glycerol ester of eicosapentaenoic acid (Cay-90110, Cay-21908), which is an omega-3 fatty acid. An EPA-TG emulsion, administered i.v., lowers leukotriene B4 production by 40% in polymorphonuclear leukocytes from rabbits and reduces platelet aggregation. It suppresses...

5(Z),8(Z),14(Z)-Eicosatrienoic acid is a polyunsaturated fatty acid that can be a substrate for 5-lipoxygenase (5-LO). 5-LO from RBL-1 cells converts this fatty acid to 5-hydroxy-6,8,14-eicosatrienoic acid and 5-hydroperoxy-6,8,14-eicosatrienoic acid. Due to the lack of a double bond at C-11, this particular fatty...

Ricinoleic acid is a naturally occurring 12-hydroxy fatty acid and constitutes about 90% of the fatty acids in castor oil. It can serve as a substrate for the synthesis of conjugated linoleic acids. Ricinoleic acid ethyl ester is a stabilized, lipid-soluble form of the free acid. It has been used to produce biofuels...

Small molecules that promote osteoblast differentiation might be useful as therapeutic agents for bone diseases such as osteoporosis. Purmorphamine is a 2,6,9-trisubstituted purine that promotes the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts. The EC50 value for...

EpETrE metabolites of arachidonic acid such as 11(12-EpETrE and 14(15)-EpETrE have been identified as endothelium derived hyperpolarizing factors with vasodilator activity. Soluble epoxide hydrolase (sEH) catalyzes the conversion of EpETrEs to the corresponding DiHETrEs thereby diminishing their activity. Inhibitors...

Nuclear factor-kappaB (NF-kappaB) is an ubiquitous transcription factor that functions to enhance the transcription of pro-inflammatory cytokines like TNF-alpha, IL-1beta, IL-6, and IL-8. QNZ is an inhibitor of NF-kappaB activation with an IC50 of 11 nM in human Jurkat cells. It also inhibits TNF-alpha production...