- Search results for Cay10009651
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6 products were found matching "Cay10009651"!
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Item number: Cay10009651-5
KIAA1363 is a recently characterized 2-acetyl monoacylglyceryl ether hydrolase that is critical to the survival and proliferation of many cancer cell lines. 2-thioacetyl MAGE is a colorimetric substrate for KIAA1363. It can readily be adapted to perform activity/inhibition studies of this new enzyme, using standard...
Keywords: | S-[2-(hexadecyloxy)-1-(hydroxymethyl)ethyl]ester, ethanethioic acid |
Application: | Bioactive lipid assays |
CAS | 112014-15-0 |
MW: | 374.6 D |
From 53.00€
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Item number: Cay10009965-1
VO-OHpic is a specific inhibitor of phosphatase and tensin homolog (PTEN, IC50 = 35 nM in vitro). Through this action, it increases cellular phosphatidylinositol 3,4,5-trisphosphate (PIP3) levels, phosphorylation of Akt, and glucose uptake in adipocytes. In mice, VO-OHpic (10 µg/kg, i.p.) decreases left ventricular...
Keywords: | (OC-6-45)-aqua(3-hydroxy-2-pyridinecarboxylato-kappaN1,kappaO2)[3-(hydroxy-kappaO)-2-pyridinecarboxylato(2-)-kappaO2]oxo-v... |
Application: | PTEN inhibitor |
CAS | 476310-60-8 |
MW: | 415.2 D |
From 44.00€
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Item number: Cay10009652-1
Histone deacetylase 4 (HDAC4) is a zinc-dependent metalloenzyme and class IIa HDAC. It is composed of an N-terminal regulatory domain, which contains a myocyte-specific enhancer factor 2 (MEF2) binding site, three 14-3-3 binding sites, a nuclear localization signal, and a caspase-3 cleavage site, a catalytic domain,...
Keywords: | HD4, HD4, HDAC4, KIAA0288, Histone deacetylase 4, Histone deacetylase 4 |
Application: | Enzyme activity |
MW: | 75,2 kD |
678.00€
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Item number: Cay10009650-1
KIAA1363 is a 2-acetyl monoacylglyceryl ether (MAGE) hydrolase that is upregulated in aggressive cancers from various tissues. The enzyme catalyzes the hydrolysis of the 2-acetyl MAGE to MAGE and serves as a central enzyme in the PAF and LPA signaling network. AS 115 is a potent and selective inactivator of...
Keywords: | N-[2-[[(1S,2R)-2-(butoxymethyl)cyclohexyl]methoxy]ethyl]-2-fluorophenyl ester-carbamic acid |
Application: | KIAA1363 inactivator |
MW: | 381.5 D |
From 81.00€
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Item number: Cay10009465-1
HDAC6 is a Class II HDAC that can shuttle between the nucleus and cytoplasm, suggesting potential extranuclear functions by regulating the acetylation status of non-histone substrates. By modifying chromatin structure and other non-histone proteins, HDACs play important roles in controlling complex biological...
Keywords: | HD6, HD6, JM21, Histone deacetylase 6, Histone deacetylase 6, Tubulin-lysine deacetylase HDAC6, Tubulin-lysine deacetylase... |
Application: | Enzyme activity |
MW: | 159 kD |
730.00€
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Item number: Cay10009645-1
Maslinic acid is found in a number of natural sources, most notably pomace olive oil (orujo). This pentacyclic triterpene has an antiproliferative effect against Caco-2 cancer cells (EC50 = 15 µM), HT-29 human colon cancer cells (EC50 = 74 µM), 1321N1 astrocytoma cells (IC50 = 25 µM), and human leukemia (CCRF-CEM...
Keywords: | 2alpha-Hydroxyoleanoic Acid, Crategolic Acid, 2alpha,3beta-dihydroxy-olean-12-en-28-oic acid |
Application: | NO production inhibitor |
CAS | 4373-41-5 |
MW: | 472.7 D |
From 42.00€
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