- Search results for Cay10009518-%25
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5 products were found matching "Cay10009518-%25"!
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Item number: Cay10009815-25
Pleckstrin homology (PH) domains all contain a seven-standard b-sandwich that allows binding to various species of phosphatidylinositol (PtdIns) phosphates. Most PH domains bind to PtdIns phosphates with weak affinity and low specificity. However, a small subclass binds specifically and with high-affinity for...
Keywords: | Phosphatidylinositol-4,5-diphosphate, PI(4,5)-P2, PIP2, PLC-delta1-PH Domain |
Application: | WB |
MW: | 45,2 kD |
From 163.00€
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Item number: Cay10009598-25
6,7-dihydroxy Bergamottin (6,7-DHB) is a potent inhibitor of CYP3A4 (IC50 = 25 µM). It appears to be the primary compound in grapefruit juice that is responsible for inhibition of testosterone 6beta-hydrolase activity. Ingestion of grapefruit juice during treatment regimes with drugs normally metabolized by...
Keywords: | 6,7-DHB, 4-[[(2E)-6,7-dihydroxy-3,7-dimethyl-2-octenyl]oxy]-7H-fuoro[3,2-g][1]benzopyran-7-one |
Application: | CYP3A4 inhibitor |
CAS | 145414-76-2 |
MW: | 372.4 D |
From 27.00€
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Item number: Cay10005189-25
PX-478 suppresses both constitutive and hypoxia-induced levels of HIF-1alpha in cancer cells, resulting in reduced expression of HIF-1alpha target genes. It induces apoptosis in human tumor xenografts in mice to an extent that is proportional to initial HIF-1alpha level. PX-478 can also increase chemo- or...
Keywords: | 4-[bis(2-chloroethyl)oxidoamino]-L-phenylalanine, dihydrochloride |
Application: | HIF-1 alpha inhibitor |
CAS | 685898-44-6 |
MW: | 394.1 D |
From 89.00€
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Item number: Cay10008669-25
Central cannabinoid (CB1) receptor antagonists and inverse agonists exhibit therapeutic potential for obesity and drug dependence, while being devoid of psychotropic effects. CAY10508 is a potent and selective central cannabinoid (CB1) receptor inverse agonist with a Ki value of 243 nM and an EC50 of 195 nM. A 10 µM...
Keywords: | 1,3-bis(4-bromophenyl)-5-phenyl-2,4-imidazolidinedione |
Application: | CB1 receptor inverse agonist |
CAS | 878533-35-8 |
MW: | 486.2 D |
From 38.00€
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Item number: Cay10009818-25
The NF-kappaB/Rel family of transcription factors is comprised of several structurally-related proteins that form homodimers and heterodimers and include p50/p105, p52/p100, RelA (p65), and c-Rel/NF-kappaB . Members of this family are responsible for regulating over 150 target genes, including the expression of...
Keywords: | NFKB1, EBP-1, DNA-binding factor KBF1, Nuclear factor NF-kappa-B p50 subunit, Nuclear factor NF-kappa-B p105 subunit,... |
Application: | WB |
MW: | 74,5 kD |
530.00€
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