AS-252424 is a potent inhibitor of phosphatidylinositol-3-kinase PI3K with selectivity for the gamma isoform. It inhibits human recombinant PI3Kgamma, alpha, beta, and delta with IC50 values of 30, 940, 20,000 and 20,000 nM, respectively. AS-252424 also inhibits C5a-mediated phosphorylation of Akt in RAW 264.7...

DNA is continually damaged by endogenous and environmental agents leading to the formation of abasic (apurinic/apyrimidinic, AP) sites that are disruptive to DNA synthesis. Aldehyde Reactive Probe (ARP) is a biotinylated reagent for the detection and quantification of AP sites in damaged DNA. ARP reacts with...

Impaired trafficking of cholesterol to or from the endoplasmic reticulum (ER) has been implicated in many disease states including Neimann-Pick disease type C (NPC), Alzheimers disease and atherosclerosis. U-18666A is a cell permeable drug that inhibits cholesterol trafficking. It inhibits cholesterol transport from...

Cytohesins are small guanine nucleotide exchange factors (GEFs) that stimulate adenosine diphosphate ribosylation factors (Arfs), GTPases which control signal transduction along various intracellular pathways. SecinH3 is a selective inhibitor of cytohesins, blocking human, mouse, and Drosophila cytohesins with IC50...