Estrogen receptor alpha (ERalpha) and ERbeta are ligand-activated transcription factors that mediate the actions of estrogen. Activation of ERalpha, but not ERbeta, is required for the cardioprotective effects of estradiol. Propylpyrazole triol (PPT) is an ERalpha selective agonist with a 410-fold relative binding...

1,2-Dipalmitoyl-sn-glycerol is a diacylglycerol that contains palmitic acid (Cay-10006627) at the sn-1 and sn-2 positions. It activates protein kinase C (PKC) by 15% when used at a concentration of 25 µM. 1,2-Dipalmitoyl-sn-glycerol promotes exponential growth of Frankia Gram-positive bacteria.Formal Name:...

1,2-Dihexanoyl-sn-glycerol is an analog of the protein kinase C (PKC)-activating second messenger diacylglycerol (DAG). Although the biological activities of 1,2-Dihexanoyl-sn-glycerol have not been well characterized, it is expected to behave similarly to 1,2-dioctanoyl-sn-glycerol (Cay-62225).Formal Name:...

gamma-Aminobutyric acid (GABA) is a major inhibitory neurotransmitter that functions by binding to the GABA receptors located in the spinal cord. Gabapentin is a gamma-aminobutyric acid (GABA) analogue that acts as an anticonvulsant with proven analgesic effects in various neuropathic pain syndromes such as Complex...