10 products were found matching "Cay10008665"!

Prostaglandin F1alpha-d9 (PGF1alpha.-d9) contains nine deuterium atoms at the 17, 17', 18, 18', 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of PGF1alpha by GC- or LC-mass spectrometry. PGF1alpha is the putative metabolite of dihomo-gamma-linolenic acid...

RCS-4 3-methoxy isomer is an RCS-4 analog whose design is based on the structure of the synthetic cannabinoid JWH 018 (Kis = 9.0 and 2.94 nM for binding to the central (CB1) and peripheral (CB2) cannabinoid receptors, respectively). The biological activity of RCS-4 3-methoxy isomer has not been reported. This...

Apart from direct peroxisome proliferator-activated receptor gamma (PPARgamma) agonism, several PPARgamma ligands have recently been shown to exert anti-diabetic effects through a second, distinct biochemical function: blocking the obesity-linked phosphorylation of PPARgamma by cyclin-dependent kinase 5 (Cdk5) at...

The enzyme fatty acyl amide hydrolase (FAAH) is widely expressed in brain and other tissues, and is capable of hydrolyzing anandamide (AEA) and other simple esters and amides with long unsaturated acyl chains. JP83 is an irreversible fatty acyl amide hydrolase (FAAH) inhibitor of the carbamate class with an IC50 of...

LY2183240 is a potent, competitive inhibitor of anandamide uptake (IC50 = 270 pM, Ki = 540 pM) and hydrolysis. It increases anandamide levels in rat cerebellum (ED50 = 1.37 mg/kg) and displays dose-dependent efficacy (3-30 mg/kg) in several rodent models of persistent pain.Formal Name:...

Central cannabinoid (CB1) receptor antagonists and inverse agonists exhibit therapeutic potential for obesity and drug dependence, while being devoid of psychotropic effects. CAY10508 is a potent and selective central cannabinoid (CB1) receptor inverse agonist with a Ki value of 243 nM and an EC50 of 195 nM. A 10 µM...

The enzyme, fatty acid amide hydrolase (FAAH), is widely expressed in brain and other tissues, and is capable of hydrolyzing anandamide (AEA) and other simple esters and amides with long unsaturated acyl chains. JP104 is an irreversible fatty acid amide hydrolase (FAAH) inhibitor of the carbamate class with an IC50...

4(Z),10(Z),13(Z),16(Z)-Docosatetraenoic acid methyl ester is a long chain polyunsaturated fatty acid. It is a minor fatty acid component of rat testis lipids. The methyl ester is a neutral, more lipophilic form of the free acid.Formal Name: 4Z,10Z,13Z,16Z-docosatetraenoic acid, methyl ester. Synonyms:...

15-keto Iloprost is the C-15 oxidized derivative of iloprost, a second generation structural analog of prostaglandin I2 (prostacyclin). Iloprost displays ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. There are no published studies of the pharmacological properties...

Pinolenic acid is a polyunsaturated fatty acid found in Korean pine (Pinus orientalis) and maritime pine (Pinus pinaster) seed oils. Both oils have been found to have lipid-lowering properties. A diet containing maritime pine seed oil (MPSO) lowered HDL and ApoA-I levels in transgenic mice expressing human ApoA-I....