Peroxisome proliferator-activated receptors (PPARs) play an essential role in regulating lipid and glucose metabolism. Oleoyl ethanolamide (OEA), a natural ligand for PPARalpha, has been shown to suppress food intake and reduce weight gain in rats when administered systemically at 10 mg/kg intraperitoneally....

N-Methyl-D-aspartate (NMDA) receptors are Ca2+ permeable ligand-gated channels of the central nervous system that are activated after binding of the co-agonists glutamate and glycine. CAY10608 is a propanolamine that potently, selectively, and non-competitively antagonizes the NR2B subunit of NMDA receptors (IC50 =...

FH535 is an inhibitor of beta-catenin/Tcf-mediated transcription and an antagonist of ligand-dependent activation of PPARgamma and PPARdelta. At 15 µM, FH535 blocks the recruitment of beta-catenin and GRIP1 to PPARgamma and PPARdelta. Presumably through these actions, FH535 is selectively toxic to some carcinoma...

Tyramine is a tyrosine-derived endogenous and dietary monoamine and trace amine-associated receptor 1 (TAAR1) agonist. It activates TAAR1 (EC50s = 0.08, 0.69, and 2.26 µM for rat, mouse, and human-rat chimera receptors, respectively). Tyramine also inhibits the release of norepinephrine and dopamine in isolated rat...