10 products were found matching "Cay10008441"!

D-myo-Inositol-1,5-phosphate (Ins(1,5)P) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)P3 is a second messenger produced in cells by phospholipase C (PLC)-mediated...

UNC0631 is a potent and selective inhibitor of G9a activity in vitro (IC50 = 4 nM) and G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC50 = 25 nM). It potently inhibits G9a/GLP activity in a variety of cancer cell lines as well as in the human fetal lung IMR-90 cell line.Formal Name:...

Estrogen receptor alpha (ERalpha) and ERbeta are ligand-activated transcription factors that mediate the actions of estrogen. Activation of ERalpha, but not ERbeta, is required for the cardioprotective effects of estradiol. Propylpyrazole triol (PPT) is an ERalpha selective agonist with a 410-fold relative binding...

D-myo-Inositol-1,3-phosphate (Ins(1,3)P2) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)P3 is a second messenger produced in cells by phospholipase C (PLC)-mediated...

The inositol phosphates (IPs) are a family of molecules produced by altering the phosphorylation status of each of the six carbons on the cyclic inositol structure. They act as second messengers, regulating a wide array of cellular functions. D-myo-inositol-1,3,4,6-tetraphosphate(Ins(1,3,4,6)-P4) largely acts an...

Limaprost is an analog of prostaglandin E1 (PGE1) with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is an inhibitor of ADP and collagen-induced platelet aggregation and is 10-1,000 times more potent than PGE1 as an inhibitor of platelet adhesiveness measured in...

D-myo-Inositol-1,2,3,5-tetraphosphate (Ins(1,2,3,5)P4) is one of the many inositol phosphate isomers that could act as small, soluble second messengers in the transmission of cellular signals. Ins(1,2,3,5)P4 exhibits relatively weak agonist activity at the Ins(1,4,5)P3 receptor expressed in CHO cells, where it...

gamma-Tocotrienol is a form of vitamin E that has been found in rice bran and has diverse biological activities. It reduces cell death induced by hydrogen peroxide, paraquat, S-nitrocysteine, SIN-1 (Cay-82220), or L-buthionine-(S,R)-sulfoximine (BSO, Cay-14484) in rat striatal cultures when used at concentrations...

The prostaglandin E1 (PGE1) Quant-PAK has been designed for the convenient, precise quantification of PGE1 by GC- or LC-mass spectrometry. It includes a 50 µg vial of PGE1-d4 and a precisely weighed vial of unlabeled PGE1, with the precise weight (2-4 mg) indicated on the vial. This unlabeled PGE1can be used to...

Ins(2,5,6)P3 (sodium salt) is a member of the inositol phosphate (InsP) family of second messengers that play a critical role in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)P3 is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of...