6 products were found matching "Cay10008201"!

Oleic acid is a monounsaturated fatty acid and is one of the major components of membrane phospholipids. It contributes about 17% of the total fatty acids esterified to phosphatidylcholine in porcine platelets. Oleic acid ethyl ester is a neutral, more lipid-soluble form of oleic acid. As the free acid, it inhibits...

D-myo-Inositol-1,4,5-triphosphate (Ins(1,4,5)P3) is a second messenger produced in cells by phospholipase C mediated hydrolysis of phosphatidyl inositol-4,5-biphosphate. It binds to one of several Ins(1,4,5)P3 receptors, each containing a calcium channel domain. Binding of Ins(1,4,5)P3 to the receptor results in...

IGFBP5 is a secreted protein that is a critical member of the IGF axis. It binds IGF-1 and restricts it from accessing its cell-surface receptor (IGF-1R). This aids in regulation of cell growth, differentiation, and apoptosis. IGFBP5 also displays IGF-1 independent transactivational activity in the nucleus. Some...

Insulin-like growth factor binding protein 5 (IGFBP5) is a secreted protein that binds IGF-1 and restricts it from accessing its cell-surface receptor (IGF-1R). This aids in regulation of cell growth, differentiation, and apoptosis. IGFBP5 also displays IGF-1 independent transactivational activity in the nucleus....

4-hydroxy Tolbutamide is a metabolite of the potassium channel antagonist tolbutamide (Cay-19888). It is formed from tolbutamide by the cytochrome P450 (CYP) isoform CYP2C9 in human liver microsomes and COS-7 cell lysates expressing the human enzyme. 4-hydroxy Tolbutamide has been used as a marker of CYP2C9 activity...

The enzyme 5-lipoxygenase (5-LO) plays a key role in regulating the production of leukotrienes (LTs). Overproduction of LTs contributes to several diseases, most notably chronic inflammatory diseases such as asthma, fibrosis, and atherosclerosis. Recent work has demonstrated that the activity of 5-LO is regulated by...