Renin is an aspartyl protease glycoprotein, a member of the aspartic acid protease family, and a hormone. It is a single-chain polypeptide in which the N- and C-terminal portions contain an aspartate residue responsible for its catalytic activity. It is formed from prorenin, a zymogen found primarily in the...

Secretory phospholipase A2 (sPLA2) (Type IIA) is a calcium-dependent PLA2 superfamily member that is encoded by PLA2G2A in humans. It is composed of a highly-conserved calcium-binding loop, a catalytic domain, sPLA2 Type I- and II-specific disulfides that provide stability, and a C-terminal extension but lacks the...

NNC 55-0396 is a selective inhibitor of T-type calcium channels that blocks Cav3.1 in stably expressing HEK293 cells (IC50 = 6.8 µM) with no discernible effect on high voltage-activated (L-type) channels in INS-1 cells up to a concentration of 100 µM. NNC 55-0396 suppresses tremor in two murine models, the GABAA...