6 products were found matching "Cay10007211"!

Prostaglandin E2 (PGE2) is one of the primary COX products of arachidonic acid (Cay-90010) and one of the most widely investigated PGs. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation. The effects of PGE2 are transduced by at least four distinct...

CAY10721 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (39% SIRT3 inhibition at 200 µM). Upregulation of SIRT3 transcription is associated with oral squamous cell carcinoma (OSCC) and breast cancer with lymph node involvement, while SIRT3 down-regulation inhibits the growth of OSCC cells and sensitizes them...

Bisindolylmaleimide III was developed as a protein kinase C (PKC) inhibitor with structural similarity to the nonspecific PKC inhibitor staurosporine. At 1 µM, bisindolylmaleimide III inhibits 93% of PKCalpha kinase activity and also inhibits many other protein kinases including, S6K1, MAPKAP-K1, RSK2 and MSK1 with...

JWH 201 (Cay-10721) is a synthetic cannabinoid (CB) with relatively poor affinities for both CB1 (Ki = 1.1 µM) and CB2 (Ki = 0.44 µM) receptors. It is a para-methoxy analog of the more potent cannabimimetic JWH 250 (Cay-13634). This product is intended for research and forensic applications.Formal Name:...

Glial fibrillary acidic protein (GFAP) is a 40-53 kDa monomeric molecule found only in adult glial cells of the central nervous system (CNS) and represents the major part of the cytoskeleton of astrocytes. Traumatic injury to the adult CNS results in a rapid inflammatory response by the resident astrocytes,...

Cathepsin K is a lysosomal cysteine protease found in osteoclasts whose elevated activity has been linked to the formation of osteoporosis and arthritis. 2-cyano-Pyrimidine is a cathepsin K inhibitor whose basic structure and derivatives are being studied for the treatment of osteoporosis. 2-cyano-Pyrimidine has an...