12(S)-HETE is a product of arachidonic acid metabolism through the 12-lipoxygenase pathway. It is primarily found in platelets, leukocytes, and to a lesser extent in smooth muscle cells. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix. tetranor-12(S)-HETE is the major...

Epoxomicin is a potent anti-tumor agent isolated from Actinomycetes that is used as a selective and irreversible inhibitor of the 20S proteasome. It inhibits proteasome activity in cell growth assays with an IC50 value of 4 nM and demonstrates potent cytotoxicity against B16-F10, HCT116, and Moser solid tumor cells,...

Molecules having vitamin E antioxidant activity include four tocopherols (alpha, beta, gamma, delta) and four tocotrienols (alpha, beta, gamma, delta). One form, alpha-tocopherol has the highest biological activity based on fetal resorption assays. delta-CEHC is a major beta-oxidation metabolite of delta-tocopherol....