8 products were found matching "Cay10006910"!

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HIF-1alpha Transcription Factor Assay Kit
HIF-1alpha Transcription Factor Assay Kit

Item number: Cay10006910-96

The HIF (hypoxia-inducible factor) transcription factor is a member of the basic-helix-loop-helix (bHLH) family of transcription factors and plays an important role in maintaining cellular oxygen homeostasis. HIF-1alpha has emerged as an important drug target in breast and prostate cancer, cardiovascular disease,...
Keywords: Hypoxia-Inducible Factor-1alpha
Application: HIF DNA binding
Species reactivity: human, mouse, rat
661.00€ *
Review
(±)17(18)-DiHETE
(±)17(18)-DiHETE

Item number: Cay10006999-100

Eicosapentaenoic acid (EPA, Cay-90110) is an omega-3 fatty acid abundantly available in marine organisms. (±)17(18)-DiHETE is one of the major metabolites produced when eicosapentaenoic acid (EPA) is incubated with various rat tissue homogenates or cynomolgus monkey seminal vesicles. The route of production of...
Keywords: (±)17,18-dihydroxy-eicosa-5,8,11,14-Tetraenoic Acid, (±)17,18-dihydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid
Application: Bioactive lipid assays
MW: 336.5 D
From 141.00€ *
Review
HTS 01037
HTS 01037

Item number: Cay10699-10

Adipocyte fatty acid binding protein (A-FABP/aP2) is a carrier protein expressed in both adipocytes and macrophages where it functions in intracellular fatty acid solubilization, trafficking, and metabolism. Molecular disruption of A-FABP/aP2 in mice results in improved insulin sensitivity and protection from...
Keywords: 4-[(3-carboxy-1-oxo-2-propen-1-yl)amino]-[2,2'-bithiophene]-5-carboxylic acid, 5-methyl ester
Application: A-FABP/aP2 antagonist
CAS 682741-29-3
MW: 337.4 D
From 43.00€ *
Review
BRD2 bromodomains 1 and 2 (human, recombinant)
BRD2 bromodomains 1 and 2 (human, recombinant)

Item number: Cay11069-100

Bromodomain-containing 2 (BRD2) is a transcriptional regulator that is a member of the bromodomain and extra-terminal (BET) family. It is ubiquitously expressed and localizes to the nucleus. BRD2 is composed of two N-terminal bromodomains (BD1 and BD2) that bind acetylated lysine on histones, serving to couple...
Keywords: BRD2, O27.1.1, O27.1.1, KIAA9001, Bromodomain-containing protein 2, Bromodomain-containing protein 2, Really interesting...
Application: Binding studies
MW: 71,2 kD
From 465.00€ *
Review
Pravadoline
Pravadoline

Item number: Cay10006973-10

Pravadoline is a nonacidic, aminoalkylindole analgesic agent that inhibits cyclooxygenase. Like NSAIDs, pravadoline inhibits prostaglandin synthesis (IC50 = 5 µM in mouse brain microsomes) and displays antinociceptive activity (ED50 = 26 mg/kg in an acetylcholine-induced writhing assay in mice). In contrast to...
Keywords: WIN 48,098, (4-methoxyphenyl)[2-methyl]-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]-methanone
Application: Analytical reference standard, COX inhibitor, NSAID
CAS 92623-83-1
MW: 378.5 D
From 274.00€ *
Review
AM630
AM630

Item number: Cay10006974-10

AM630 binds selectively to cannabinoid 2 (CB2) over CB1 receptors with Ki values of 31.2 and 5,152 nM, respectively. AM630 acts as an inverse agonist at CB2 receptors, attenuating the antinociceptive effects of a number of cannabinoids, and as a weak partial agonist at CB1 receptors. It decreases proliferation and...
Keywords: 6-Iodopravodoline, [6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)-methanone
Application: CB2 receptor antagonist
CAS 164178-33-0
MW: 504.4 D
From 77.00€ *
Review
Zileuton
Zileuton

Item number: Cay10006967-10

Zileuton is a reversible 5-lipoxygenase (5-LO) inhibitor. It inhibits 5-LO activity in rat basophilic leukemia-1 (RBL-1) cell supernatant with an IC50 value of 0.5 µM. Zileuton inhibits leukotriene B4 (LTB4, Cay-20110) production induced by the calcium ionophore A23187 (Cay-11016) in purified human peripheral blood...
Keywords: A 64077, N-(1-benzo[b]thien-2-ylethyl)-N-hydroxy-urea
Application: 5-LO inhibitor
CAS 111406-87-2
MW: 236.3 D
From 28.00€ *
Review
AM281
AM281

Item number: Cay10006972-10

AM281 is a potent and selective central cannabinoid (CB1) receptor antagonist/inverse agonist (Kis = 12 nM and 4,200 nM for CB1 and CB2, respectively). Structurally, it is an analog of the CB1 inverse agonist rimonabant (Cay-9000484). It has no effect on the vanilloid TRPV1 receptor. AM281 has been used to evaluate...
Keywords: 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide
Application: Forensic studies, Difuran analog
CAS 202463-68-1
MW: 557.2 D
From 33.00€ *
Review