Numerous analogs of arachidonoyl ethanolamide (AEA) potentiate its biological activity. This potentiation is ascribed either to inhibition of AEA reuptake into neurons, or inhibition of fatty amide acyl hydrolase (FAAH) within the neurons. VDM11 is an AEA transport inhibitor with essentially no activity on either...

Deficiency of vitamin D leads to abnormal calcium and phosphorus metabolism, contributing to deficiencies in bone formation, neuromuscular function, and inflammatory response. 25-hydroxy Vitamin D3 is an intermediate in the pathway leading to the production of 1,25-dihydroxy vitamin D3, the most receptor-active form...

JWH 030 (Cay-10831) is a naphthoyl pyrrole cannabimimetic which activates the CB1 receptor (EC50 = 30.5 nM for rat, Ki = 87 nM for mouse) better than CB2 (EC50 = 552 nM for human CB2). JWH 030 is quite potent in vivo in the mouse spontaneous activity and tail flick (antinociception) assays (ED50 = 26.8 µM/kg). It...

Oxidized low-density lipoprotien (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at...

Roseoflavin is an analog of flavin mononucleotide (FMN) and riboflavin that is synthesized by the soil bacterium S. davawensis and possesses antimicrobial activity. It has been shown to bind directly to FMN riboswitch aptamers (KD = ~100 nM), downregulating the expression of genes responsible for the synthesis and...