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Cay10006426-1
CAS: 213261-​59-​7
p53-​HDM-​2 interaction inhibitor Erklärungen der Abkürzungen ansehen.
RITA (reactivation of p53 and induction of tumor cell apoptosis) is a small molecule inhibitor of p53-HDM-2 interaction that can reactivate the tumor suppressor function of wild-type p53. It binds to p53 with an apparent Kd of 1.5 nM and prevents interaction with HDM-2 resulting in p53 stabilization, accumulation and activation. RITA potently inhibits the growth of a variety of cancer cell lines in the sub-micromolar range, inducing both DNA-protein and DNA-DNA cross links in human renal cancer cells. RITA reduced tumor size by 90% at a dose of 10 mg/kg in SCID mice bearing HCT116 tumors, and caused complete regression of A-498 tumor cell xenografts in nude mice at a dose of 45 mg/kg.

MW: 292 D
Formula: C14H12O3S2
Purity: >98%
Cayman
Icon Datasheet
1 mg

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59 €

Cay10006426-10
CAS: 213261-​59-​7
p53-​HDM-​2 interaction inhibitor Erklärungen der Abkürzungen ansehen.
RITA (reactivation of p53 and induction of tumor cell apoptosis) is a small molecule inhibitor of p53-HDM-2 interaction that can reactivate the tumor suppressor function of wild-type p53. It binds to p53 with an apparent Kd of 1.5 nM and prevents interaction with HDM-2 resulting in p53 stabilization, accumulation and activation. RITA potently inhibits the growth of a variety of cancer cell lines in the sub-micromolar range, inducing both DNA-protein and DNA-DNA cross links in human renal cancer cells. RITA reduced tumor size by 90% at a dose of 10 mg/kg in SCID mice bearing HCT116 tumors, and caused complete regression of A-498 tumor cell xenografts in nude mice at a dose of 45 mg/kg.

MW: 292 D
Formula: C14H12O3S2
Purity: >98%
Cayman
Icon Datasheet
10 mg

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195 €

Cay10006426-5
CAS: 213261-​59-​7
p53-​HDM-​2 interaction inhibitor Erklärungen der Abkürzungen ansehen.
RITA (reactivation of p53 and induction of tumor cell apoptosis) is a small molecule inhibitor of p53-HDM-2 interaction that can reactivate the tumor suppressor function of wild-type p53. It binds to p53 with an apparent Kd of 1.5 nM and prevents interaction with HDM-2 resulting in p53 stabilization, accumulation and activation. RITA potently inhibits the growth of a variety of cancer cell lines in the sub-micromolar range, inducing both DNA-protein and DNA-DNA cross links in human renal cancer cells. RITA reduced tumor size by 90% at a dose of 10 mg/kg in SCID mice bearing HCT116 tumors, and caused complete regression of A-498 tumor cell xenografts in nude mice at a dose of 45 mg/kg.

MW: 292 D
Formula: C14H12O3S2
Purity: >98%
Cayman
Icon Datasheet
5 mg

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124 €

Cay10006426-50
CAS: 213261-​59-​7
p53-​HDM-​2 interaction inhibitor Erklärungen der Abkürzungen ansehen.
RITA (reactivation of p53 and induction of tumor cell apoptosis) is a small molecule inhibitor of p53-HDM-2 interaction that can reactivate the tumor suppressor function of wild-type p53. It binds to p53 with an apparent Kd of 1.5 nM and prevents interaction with HDM-2 resulting in p53 stabilization, accumulation and activation. RITA potently inhibits the growth of a variety of cancer cell lines in the sub-micromolar range, inducing both DNA-protein and DNA-DNA cross links in human renal cancer cells. RITA reduced tumor size by 90% at a dose of 10 mg/kg in SCID mice bearing HCT116 tumors, and caused complete regression of A-498 tumor cell xenografts in nude mice at a dose of 45 mg/kg.

MW: 292 D
Formula: C14H12O3S2
Purity: >98%
Cayman
Icon Datasheet
50 mg

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918 €


 

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