Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transcription factor that accumulates under low-oxygen conditions. Following hypoxic stimulus and cytoplasmic accumulation, HIF-1alpha migrates to the nucleus where with other transcription factors, it drives the production of stress-adaptive proteins. This response...

Soluble epoxide hydrolase (sEH) inhibitors have important therapeutic use by increasing the in vivo concentration of EETs and other fatty acid epoxides, resulting in anti-inflammatory, antihypertensive, neuroprotective, and cardioprotective effects. CAY10640 is a 1-aryl-3-(1-acylpiperidin-4-yl)urea analog that...

HDM-2 (human double minute-2, MDM-2 in mouse) is a key negative regulator of p53 that binds to and targets p53 for proteasomal degradation. Overexpression of HDM-2 in some tumors leads to inactivation of p53 thereby allowing tumor cells to escape p53-induced apoptosis. RITA is an inhibitor of the protein-protein...

Berberine is an isoquinoline alkaloid that has been found in C. fenestratum and has diverse biological activities. It induces frameshift mutations and gene crossovers in haploid and diploid strains of S. cerevisiae in the exponential growth phase, respectively, when used at a concentration of 50 µg/ml. Berberine is...