- Search results for Cay10005537-%25
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6 products were found matching "Cay10005537-%25"!
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Item number: Cay10009078-25
Phosphoinositide 3-kinase gamma (PI3Kgamma), expressed primarily in hematopoietic cells, plays several important roles in immunity. CAY10505 is a potent inhibitor of PI3K, selectively inhibiting the gamma isoform (IC50 = 30 nM) better than the alpha, beta, and delta isoforms (IC50 = 0.94, 20, and 20 µM,...
Keywords: | 5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione |
Application: | PI3K inhibitor |
CAS | 328960-84-5 |
MW: | 289.3 D |
From 50.00€
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Item number: Cay10010396-25
TPalpha and TPbeta are two isoforms of the human TP receptor, the G protein-coupled receptor (GPCR) that mediates the actions of thromboxane A2 (TXA2). Although their distinct physiological functions have not been fully elucidated, TPbeta is believed to be responsible for vascular endothelial growth factor-induced...
Keywords: | N-(tert-butylcarbamoyl)-2-(3-methoxyphenoxy)-5-nitrobenzenesulfonamide |
Application: | TP receptor antagonist |
CAS | 945716-28-9 |
MW: | 423.4 D |
From 48.00€
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Item number: Cay10005537-5
N-Arachidonoyl taurine is an arachidonoyl amino acid. It is oxygenated by 12(S)- and 15(S)-lipoxygenase and is converted to 12-HETE-taurine (12-HETE-T) in murine resident peritoneal macrophages. N-Arachidonoyl taurine is an activator of the transient receptor potential vanilloid (TRPV) channels TRPV1 and TRPV4...
Keywords: | 2-[(1-oxo-5Z,8Z,11Z,14Z-eicosatetraenyl)amino]-ethane sulfonic acid |
Application: | Bioactive lipid assays |
CAS | 119959-65-8 |
MW: | 411.6 D |
From 58.00€
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Item number: LKT-C0396.25
CAY10505 is an inhibitor of p110 PI3K. CAY10505 increases endothelial relaxation, normalizes levels of glutathione, nitrate, and nitrite, and alters the vascular endothelial lining in hypertensive rats, improving vascular endothelial dysfunction.
Keywords: | 5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione |
Application: | PI3K p110 inhibitor |
CAS | 1218777-13-9 |
MW: | 289.28 D |
From 84.00€
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Item number: Cay15007-25
Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.Formal Name:...
Keywords: | DOX,... |
Application: | DNA topoisomerase II inhibitor, Antitumor agent |
CAS | 25316-40-9 |
MW: | 580 D |
From 43.00€
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Item number: Cay15037-25
Mibefradil is a general calcium channel blocker that shows modest selectivity for T-type channels over L-type channels (IC50 = 2.7 and 18.6 µM, respectively). It is a potent vasodilator, increasing coronary artery flow with an EC50 value of 54 nM. Mibefradil has minimal negative inotropic effects, supporting its use...
Keywords: | Posicor, Ro 40-5967,... |
Application: | Calcium channel blocker, Vasodilator |
CAS | 116666-63-8 |
MW: | 568.6 D |
From 142.00€
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