9 products were found matching "Cay10004910"!

4-methoxy-alpha-Pyrrolidinopropiophenone (tosylate) (Cay-10449), also known as MOPPP, is an analytical reference standard that is structurally categorized as a cathinone. It is a designer drug that has appeared on the illicit drug market. Its metabolism in rats has been described. The physiological and toxicological...

Cyclooxygenase 2 (COX-2) is a 72 kDa protein that has been cloned from a variety of species including human, mouse, rat, and ovine. This preparation of COX-2 microsomes was prepared by solubilization and dilution of the 100,000 x g pellet from the lysate of cytokine-stimulated mouse macrophage cultures. Cayman's...

6(S)-Lipoxin A4 (6(S)-LXA4) is an isomer of the trihydroxy fatty acid LXA4 (Cay-90410). It is formed from arachidonic acid (Cay-90010, Cay-90010.1, Cay-10006607) through double lipoxygenase-catalyzed reactions initiated by either 5-lipoxygenase (5-LO) followed by 12- or 15-LO, with a leukotriene A4 (LTA4)...

Leptomycin B is a potent inhibitor of the nuclear export of proteins. It directly blocks the interaction of CRM1 (exportin 1) with nuclear export signals (NES), preventing the export of a broad range of proteins. Leptomycin B will also indirectly inhibit the export of mRNA from the nucleus by blocking the nuclear...

Ionomycin is a calcium ionophore originally isolated from S. conglobatus. It induces intracellular calcium mobilization in X. laevis oocytes when used at a concentration of 5 µM. Ionomycin (5 µM) induces the formation of neutrophil extracellular traps (NETs) in isolated human neutrophils. Ionomycin in combination...

Abnormal cannabidiol is a synthetic regioisomer of cannabidiol that fails to elicit either central cannabinoid (CB1) or peripheral cannabinoid (CB2) responsiveness and is without psychotropic activity. It induces endothelium-dependent vasodilation via a CB1/CB2/nitric oxide-independent mechanism. O-1918 is a...

Epoxyeicosatrienoic acids (EETs), lipid mediators synthesized from arachidonic acid by cytochrome P-450 epoxygenases, are converted by soluble epoxide hydrolase (sEH) to the corresponding dihydroxyeicosatrienoic acids (DHETs). N,N' Dicyclohexylurea (DCU) is a selective sEH inhibitor with IC50 values of 160 and 90 nM...

Cloprostenol is a synthetic derivative of prostaglandin F2alpha that is used in veterinary medicine as a luteolytic agent for the induction of estrus and in the treatment of reproductive disorders in cattle, swine, and horses. (+)-5-trans Cloprostenol is a minor impurity produced in the synthesis of...

Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a negative regulator of p53 activity. Caylin-1 is a nutlin-3 analog which contains chlorine substituents at the 3 and 4 positions on two of the phenyl rings rather than a single 4-chloro as seen in nutlin-3. At high...