The proliferating cell nuclear antigen (PCNA) becomes detectable in the G1 phase of the cell cycle and reaches a maximum level of expression during mitosis. PCNA is highly conserved across species and is a critical part of the DNA polymerase delta holoenzyme. The level of PCNA expression depends on the proliferative...

The early stage of atherosclerosis is characterized by the aggregation of foam cells, so called a fatty streak, in the inner arterial wall. CAY10487 inhibits formation of fatty streak lesions of the thoracic aorta in high cholesterol-fed rabbits without affecting plasma lipid profiles or significantly inhibiting...