Mitochondrial release of cytochrome c triggers apoptosis via the assembly of a multimeric complex including caspase-9, Apaf-1, and other components, sometimes called the apoptosome. Library screens have identified small molecules that activate the apoptosome by binding to one or more of its components. CAY10443 is...

Apoptosis activator 2 promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome, thus increasing procaspase-9 processing and subsequent caspase-3 activation. This compound has been shown to induce apoptosis in leukemia cells (IC50 = 4-9 µM) with weak or no effect on normal cell lines...

Ionomycin is a calcium ionophore originally isolated from S. conglobatus. It induces intracellular calcium mobilization in X. laevis oocytes when used at a concentration of 5 µM. Ionomycin (5 µM) induces the formation of neutrophil extracellular traps (NETs) in isolated human neutrophils. Ionomycin in combination...

Matairesinol is a lignan that has been found in Forsythia and has diverse biological activities. It reduces LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2, Cay-14010) in RAW 264.7 cells. Matairesinol is cytotoxic to colon 26 cancer cells (LC50 = 9 µg/ml). It increases the lifespan of C....