12 products were found matching "Cay13711"!

No results were found for the filter!
ST638
ST638

Item number: Cay13337-1

ST638 is a tyrosine kinase inhibitor (IC50 = 370 nM). It suppresses tyrosine phosphorylation induced by tumor necrosis factor-alpha and phorbol myristate acetate in neutrophils and by angiotensin II in cardiac fibroblasts.Formal Name: 2-cyano-3-[3-ethoxy-4-hydroxy-5-[(5-phenylthio)methyl]phenyl]-2-propenamide. CAS...
Keywords: 2-cyano-3-[3-ethoxy-4-hydroxy-5-[(5-phenylthio)methyl]phenyl]-2-propenamide
Application: Tyrosine kinase inhibitor
CAS 107761-24-0
MW: 354.4 D
From 52.00€ *
Review
Anti-KCNQ1 Potassium Channel   (Clone S37A-10)
Anti-KCNQ1 Potassium Channel (Clone S37A-10)

Item number: Cay13711-100

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells and their main function is to...
Keywords: Anti-KCNQ1, Anti-KCNA8, Anti-KQT-like 1, Anti-Voltage-gated potassium channel subunit Kv7.1, Anti-Potassium voltage-gated...
Application: ICC, IHC, IP, WB
Host: Mouse
Species reactivity: human
530.00€ *
Review
CAY10621
CAY10621

Item number: Cay13371-1

CAY10621 is an inhibitor of sphingosine kinase 1 (SPHK1, IC50 = 3.3 µM). It is selective for SPHK1 over SPHK2 at 10 µM and PKC at concentrations less than 100 µM. CAY10621 inhibits SPHK1 activity by 70% in U937 cells when used at a concentration of 5 µM.Formal Name:...
Keywords: SKI 5C, SPHK1 Inhibitor 5C, (4S)-2,2-dimethyl-4-(1-oxo-2-hexadecyn-1-yl)-3-oxazolidinecarboxylic acid, 1,1-dimethylethyl...
Application: SPHK 1 inhibitor
CAS 120005-55-2
MW: 435.6 D
From 38.00€ *
Review
15(R)-Prostaglandin E1
15(R)-Prostaglandin E1

Item number: Cay13710-1

15(R)-PGE1 is the "unnatural" C-15 stereoisomer of PGE1. It is essentially inactive biologically when compared to PGE1. It is a non-competitive inhibitor of 15-hydroxy PGDH with an IC50 of 189 µM.Formal Name: 9-oxo-11alpha,15R-dihydroxy-prost-13E-en-1-oic acid. CAS Number: 20897-91-0. Synonyms: 15(R)-PGE1, 15-epi...
Keywords: 15(R)-PGE1, 15-epi PGE1, 9-oxo-11alpha,15R-dihydroxy-prost-13E-en-1-oic acid
Application: PGDH inhibitor
CAS 20897-91-0
MW: 354.5 D
From 97.00€ *
Review
TAK-242
TAK-242

Item number: Cay13871-1

TAK-242 is an antagonist of toll-like receptor 4 (TLR4) with an IC50 value of 0.68 µM in a secreted alkaline phosphatase (SEAP) assay. It selectively binds to TLR4 over TLR1-3 and TLR5-10 when used at a concentration of 100 nM. TAK-242 (1 µM) prevents the interaction of TLR4 with its adaptor proteins TIRAP or TRAM...
Keywords: Resatorvid, 6R-[[(2-chloro-4-fluorophenyl)amino]sulfonyl]-1-cyclohexene-1-carboxylic acid, ethyl ester
Application: TLR4 adaptor binding inhibitor
CAS 243984-11-4
MW: 361.8 D
From 98.00€ *
Review
Butaprost (free acid)
Butaprost (free acid)

Item number: Cay13741-1

Butaprost is an EP2 selective agonist which has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells. Prostaglandin free acids generally bind to their cognate receptors with 10 to 100 times the affinity of the corresponding ester...
Keywords: (±)-15-deoxy-16S-hydroxy-17-cyclobutyl PGE1, 15-deoxy-16S-hydroxy-17-cyclobutyl PGE1,...
Application: EP2 receptor agonist
CAS 433219-55-7
MW: 394.6 D
From 142.00€ *
Review
Anti-SET7/9
Anti-SET7/9

Item number: Cay13731-1

Diverse signal transduction pathways impinging on the N-terminal tails of histones lead to a number of post-translational modifications including acetylation, phosphorylation, poly(ADP-ribosylation), ubiquitination, and methylation. These modifications play critical roles in regulating chromatin structure and gene...
Keywords: Anti-SETD7, Anti-SET7/9, EC=2.1.1.43, Anti-KIAA1717, Anti-H3-K4-HMTase SETD7, Anti-Lysine N-methyltransferase 7, Anti-SET...
Application: WB
Host: Rabbit
Species reactivity: human
432.00€ *
Review
Anti-NF-kappaB (p65) NLS
Anti-NF-kappaB (p65) NLS

Item number: Cay13751-1

NF-kappaB p65 is a ubiquitously expressed transcription factor that is a subunit of the NF-kappaB complex and is encoded by the RELA gene in humans. It is composed of an N-terminal Rel homology domain, which contains the nuclear localization signal (NLS), and mediates dimerization, nuclear localization, and DNA and...
Keywords: NF-kappaB3, Nuclear Factor-kappaB (p65) Nuclear Localization Signal, Transcription Factor p65
Application: ICC, IF, IHC, IHC (paraffin), WB
Host: Rabbit
417.00€ *
Review
Anti-Histone H3
Anti-Histone H3

Item number: Cay13781-1

Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei. It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various...
Keywords: Anti-H3FA, Anti-H3FL, Anti-H3FB, Anti-H3FD, Anti-H3FI, Anti-H3FH, Anti-H3FK, Anti-H3FF, Anti-H3FJ, Anti-Histone H3.1,...
Application: ELISA, FC, IP, WB
Host: Rabbit
Species reactivity: human
422.00€ *
Review
Anti-TRF2
Anti-TRF2

Item number: Cay13791-1

Telomeric repeat binding factor (TRF2) is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1, contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect...
Keywords: Telomeric Repeat Binding Factor 2, TERF2, TRBF2, TTAGGG Repeat Binding Factor 2
Application: ChIP, ICC, IF, IHC, IP, WB
Host: Goat
Species reactivity: human
417.00€ *
Review
ZLJ-6
ZLJ-6

Item number: Cay13271-1

ZLJ-6 is a dual inhibitor of COX and 5-lipoxygenase (5-LO) (IC50 = 0.73, 0.31, and 0.99 µM for COX-1, COX-2, and 5-LO, respectively, in whole blood). It reduces carrageenin-induced paw edema (inflammation) in rats and acetic acid-induced abdominal constriction (pain) in mice without causing gastrointestinal ulcers,...
Keywords: (5Z)-2-amino-1,5-dihydro-1-methyl-5-[[4-(methylsulfonyl)phenyl]methylene]-4H-imidazol-4-one, monomethanesulfonate
Application: COX inhibitor, 5-LO inhibitor
CAS 1051931-39-5
MW: 375.4 D
From 53.00€ *
Review
Wortmannin-Rapamycin Conjugate
Wortmannin-Rapamycin Conjugate

Item number: Cay13671-1

Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) act synergistically in promoting cancer. Wortmannin is a potent inhibitor of PI3K enzymes, while rapamycin blocks mTOR Complex 1 TORC1. Wortmannin-rapamycin conjugate consists of analogs of 17-hydroxy wortmannin and rapamycin conjugated via a...
Keywords: 1-(4S,4aR,5R,6aS,7S,9aR,E)-1-(((3-(dimethylamino)propyl)(methyl)amino)methylene)-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-di...
Application: PI3K/TORC1 inhibitors
CAS 1067892-47-0
MW: 1598.9 D
From 204.00€ *
Review