Anti-Cul7

Anti-Cul7
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A300-224A-T 10 µl (10 µg) -

2 - 8 business days*

164.00€
A300-224A 100 µl (100 µg) -

2 - 8 business days*

588.00€
 
Protein function: Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the... more
Product information "Anti-Cul7"
Protein function: Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development (PubMed:20139075). Does not promote polyubiquitination and proteasomal degradation of p53/TP53 (PubMed:16547496, PubMed:17332328). While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may be have additional functions. [The UniProt Consortium]
Keywords: Anti-CUL7, Anti-CUL-7, Anti-KIAA0076, Anti-Cullin-7
Supplier: Bethyl Laboratories
Supplier-Nr: A300-224A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: rat)
Immunogen: synthetic peptide. The epitope recognized by A300-224A maps to a region between residues 1650 and the C-terminus (residue 1698) of human Cullin homolog 7 using the numbering given in SwissProt entry Q14999 (GeneID 9820).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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