17 products were found matching "2813-1"!

The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3' side of uridine nucleotides. Alternative splicing results in four transcript variants encoding the same protein. This gene and the gene that encodes...

This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been...

Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....

Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....

This MAb reacts with MUC1, a large transmembrane glycoprotein expressed on the ductal surface of normal glandular epithelia. It is used as tracer agent in CA15.3 assays. The extracellular domain of MUC1 largely consists of a highly conserved, O-glycosylated 20 amino acids tandem repeat which can occur 30-100 times...

SR-12813 is a 1,1-bisphosphonate ester that exhibits hypocholesterolemic activity by enhancing the degradation of HMG-CoA reductase in various animal models. SR-12813 is also a high affinity ligand for human and rabbit pregnane X receptors (Kd = 41 nM, EC50 = 137 nM for hPXR in vitro) and can induce cytochrome P450...

Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death. Protein function: Serine/threonine kinase which acts as an essential component of the MAP kinase...

JNJ-42756493 is a pan-FGFR inhibitor (IC50s = 1.2, 2.5, 3, and 5.7 nM for FGFR1, -2, -3, and -4, respectively). It is selective for FGFRs over VEGFR2 (IC50 = 36.8 nM). JNJ-42756493 inhibits the proliferation of Ba/F3 cells expressing FGFR1, -3, or -4 (IC50s = 22.1, 13.2, and 25 nM, respectively). It reduces tumor...

SGC-iMLLT is an inhibitor of the YEATS domain-containing proteins MLLT1 and MLLT3. It binds to the MLLT1 YEATS1 and MLLT3 YEATS3 domains (Kds = 129 and 77 nM, respectively). It is selective for YEATS1 and -3 over YEATS2 and -4 (IC50s = >10 µM), as well as a panel of 48 bromodomains at 50 µM. SGC-iMLLT inhibits the...

Methylisothiazolinone (MI) is an isothiazolinone-derived biocide. It is active against Gram-positive and Gram-negative bacteria, as well as fungi, when used in combination with methylchloroisothiazolinone (MCI) with MIC values of 0.0002, 0.0002, 0.00005, and 0.00005% (w/w) for S. aureus, P. aeruginosa, A. niger, and...

Eprinomectin B1a is a major component (>90%) of the antiparasitic compound eprinomectin, which also contains eprinomectin B1b (27994) and belongs to the avermectin family of insecticides and anthelmintics.Formal Name: (4''R)-4''-(acetylamino)-5-O-demethyl-4''-deoxy-avermectin A1a. CAS Number: 133305-88-1. Molecular...

Decatromicin B is a bacterial metabolite that has been found in Actinomadura. It is active against Gram-positive bacteria, including several strains of S. aureus (MICs = 0.39-0.78 µg/ml), two strains of methicillin-resistant S. aureus (MRSA, MICs = 0.39 and 0.78 µg/ml), as well as M. luteus, B. subtilis, and C....