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Anti-NMDA NR2B Subunit, N-terminus

ART NR.: 1503-NR2B (100 µl)

Hersteller: PhosphoSolutions

Datenblatt

Anwendungen: WB, IHC

Format: affinity purified

Wirt: Rabbit

Reaktivität: rat, mouse, human, bovine, chicken, non-human primate, canine

Immunogen: synthetic peptide from the N-terminus of the NR2B subunit of rat NMDA receptor

UniProt ID: Q00960
Suche mit UniProt ID

Geninformationen: GeneID 24410

Schlagworte: Anti-NR2B, Anti-Grin2b, Anti-NMDAR2B, Anti-N-methyl D-aspartate receptor subtype 2B, Anti-Glutamate [NMDA] receptor subunit epsilon-2

1503-NR2B

100 µl

419 €

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Bemerkungen: The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989, Alvestad et al., 2003, Snell et al., 1996). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be clonedand it can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. Overexpression of the NR2B-subunit of the NMDA receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression (Clayton et al., 2002a, Clayton et al., 2002b). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999).

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