Chk1 functions as a checkpoint protein kinase that is critical to the regulation of the Cdc25a and Cdc25c phosphatases that promote S and G2/M phase progression, respectively. Chk1 kinase activity inhibits cell cycle progression in the presence of DNA damage by phosphorylating Cdc25a and Cdc25c and causing the degradation of Cdc25a and cytoplasmic sequestration of Cdc25c. Alternate designations for Chk1 include serine/threonine-protein kinase Chk1, and CHEK1.
Goat IgG SR: human
Immunogen: synthetic peptide. The epitope recognized by A300-162A maps to a region between residues 250 and 300 of human Checkpoint Kinase 1 using the numbering given in entry NP_001265.1 (GeneID 1111).
UniProt ID: O14757
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Products for: CHK1 - serine/threonine-protein kinase Chk1 [EC:220.127.116.11]
EC=18.104.22.168, Anti-Chk1, Anti-CHEK1, Anti-Homolog of S. pombe checkpoint 1., antibody, antibodies, Antikörper