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Anti-Chk1

ART NR.: A300-162A-T (20 µl / 2 blots)
A300-162A-M (100 µl / 10 blots)
A300-162A (100 µl / 100 µg)

Hersteller: Bethyl

Datenblatt



MSDS

Anwendungen: WB, IP, PLA

Format: antigen affinity purified

Wirt: Goat

Isotyp: IgG

Reaktivität: human (expected: dog, pig, panda, orangutan, rhesus monkey, gorilla, chimpanzee, small-eared galago, northern white-cheeked gibbon)

Immunogen: synthetic peptide. The epitope recognized by A300-162A-T maps to a region between residues 250 and 300 of human Checkpoint Kinase 1 using the numbering given in entry NP_001265.1 (GeneID 1111).

Lagerung: +4°C

Versand: +4°C

UniProt ID: O14757 | Suche mit UniProt ID

Gene ID: Gene ID 1111 | Suche mit Gene ID

KEGG ID: K02216 | Suche mit KEGG ID

Schlagworte: Anti-CHK1, Anti-CHEK1, EC=2.7.11.1, Anti-Checkpoint kinase-1, Anti-CHK1 checkpoint homolog, Anti-Cell cycle checkpoint kinase, Anti-Serine/threonine-protein kinase Chk1

A300-162A-T

20 µl (2 blots)

57 €

A300-162A-M

100 µl (10 blots)

260 €

A300-162A

100 µl (100 µg)

393 €

Größe wählen:
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Bemerkungen: Chk1 functions as a checkpoint protein kinase that is critical to the regulation of the Cdc25a and Cdc25c phosphatases that promote S and G2/M phase progression, respectively. Chk1 kinase activity inhibits cell cycle progression in the presence of DNA damage by phosphorylating Cdc25a and Cdc25c and causing the degradation of Cdc25a and cytoplasmic sequestration of Cdc25c. Alternate designations for Chk1 include serine/threonine-protein kinase Chk1, and CHEK1.

Spezifikationen

Chk1 Antibody

Goat anti-Chk1 Antibody, Affinity Purified
Chk1 AntibodyChk1 AntibodyChk1 Antibody
Chk1 AntibodyChk1 AntibodyChk1 Antibody

Gene and Protein Information

Citations

Xie J et al., FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response. PLoS Genet. 2012 Jul;8(7):e1002786. IP, WB
PubMed: 22792074
Xie J et al., An MLH1 mutation links BACH1/FANCJ to colon cancer, signaling, and insight toward directed therapy. Cancer Prev Res (Phila). 2010 Nov;3(11):1409-16. WB
PubMed: 20978114
Schroering AG et al., Prolonged cell cycle response of HeLa cells to low-level alkylation exposure. Cancer Res. 2009 Aug 1;69(15):6307-14. WB
PubMed: 19638578
Sun TP et al., Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress. Oncogene. 2009 May 7;28(18):1971-81.
PubMed: 19330022

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