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42 life sciences

Minicatalog

A brief overview about 42 Life Sciences innovative reagents for immunohistochemistry and in situ hybridization. Released May 2011.

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AAT Bioquest

Cell Apoptosis & Proliferation

  • Apoptosis
  • Cell Proliferation
  • Cell Viability and Cytotoxicity

Released October 2013.

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Cell Analysis Probes & Assay Kits

  • Tools for Fluorescence Imaging & Flow Cytometry
  • Cell Labeling and Tracking Probes
  • Subcellular Compartment Labeling Probes
  • Reporter Gene Analysis

Released August 2013.

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Physiological Probes & Assay Kits

  • Calcium Ion Detection
  • Zinc Ion Detection
  • Intracellular pH Probes
  • Anion Detection
  • Membrane Potential Measurement

Released August 2013.

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Fluorescent Labeling of Antibodies & Biopolymers

  • Fluorescence Labeling Principles
  • iFluor™ Fluorescent Labeling Dyes
  • mFluor™ Fluorescent Labeling Dyes
  • Phycobiliproteins and Their Tandem Conjugates
  • trFluor™ Fluorescent Labeling Dyes

Released October 2012.

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Abgent

GPCR Antibodies

G protein-coupled receptors (GPCRs) are the largest family of transmembrane receptors and are responsible for the transduction of a diverse range of extracellular signals. The range of physiological processes mediated by GPCRs makes them one of the most important classes of proteins for drug discovery. Released April 2014.

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Product Overview

  • Autophagy Antibodies
  • Stem Cell Antibodies
  • Protein Modification Antibodies
  • Apoptosis Antibodies
  • Neurosciences Antibodies

Released February 2013.

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Neuroscience Antibodies

  • Neural Chaperone Overview
  • Parkinson’s Genes & Loci
  • Featured Neuroscience Products

Released February 2013.

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Stem Cell Antibodies

  • Abgent and Stem Cells
  • Key Stem Cell Markers
  • SOX9, OCT4, NANOG, LIN28B, c-KIT and KLF4 Antibodies

Released February 2013.

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Autophagy Antibodies

  • Abgent and Autophagy
  • Autophagy, a Survival Guide
  • LC3: A Hallmark Autophay Protein
  • Autophagy Antibodies

Released February 2013.

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AdipoGen

Autophagy Modulators

Autophagy represents a homeostatic cellular mechanism for the turnover of organelles and proteins through a lysosome-dependent degradation pathway. Misfolded or aggregated proteins are removed, damaged organelles such as mitochondria, endoplasmic reticulum and peroxisomes are cleared and intracellular pathogens are eliminated. Released May 2014.

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Obesity & Diabetes Research

Focus: Brown, Brite/Beige and White Adipose Tissue.

  • Adipokines Obesity-related ELISA Kits
  • Obesity-related Antibodies & Proteins
  • Brown & Brite/Beige Adipocytes
  • Small Molecule Modulators

Updated May 2014.

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Cancer Research Flyer

ELISA Kits, Notch Signaling, TNF Superfamily and many unqiue Small Molecules from AdipoGen. Updated April 2014.

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Functional Antibodies

  • Blocking/Neutralizing Antibodies
  • Inducing/Activating Antibodies
  • Depleting Antibodies
  • Functional Antibodies from Ancell
  • Recombinant Monoclonal Antibodies

Released February 2014.

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Chemodex - Markers, Probes, Stains & Labels

Chemodex is an expert in the synthesis of fluorescent substances derived from fluorophores such as coumarin, fluorescein, rhodamine and pyrene. The reagents are used as probes, stains, markers, NIRlabels, pH-sensors, ion indicators, chelators and in other applications. Released January 2014.

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Betatrophin - Controlling β Cell Replication

Betatrophin (also called RIFL, Lipasin or Angiopoietin-like protein 8 (ANGPTL8)) is a new secreted protein of 198 aa that promotes β cell proliferation and improves glucose tolerance in mice. Updated January 2014.

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MultimericLigands™ Flyer

AdipoGen® Multimeric Proteins are high activity constructs in which two trimeric TNFSF ligands are linked via the oligomeric collagen domain of ACRP30 [ACRP30headless] and therefore mimic the membrane-bound forms of the proteins. Released January 2014.

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ManRos™ Reagents - Lead Compounds

ManRos Reagents™ is supplying potent pharmacological inhibitors of selected protein kinases against targeted diseases to the research market. All reagents are originally based on natural products. Released November 2013.

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AdipoChem™ - Small Molecules

AdipoChem™ is the Biochemicals business division of Adipogen International which was started by former ALEXIS Corporation scientists, manufacturing small molecules, rare antibiotics and natural products. Released November 2013.

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Interleukins - Focus: IL-1 Family & Other Newcomers

IL-1 family members, including the new members IL-33, IL-36, IL-37 and IL-38 act on innate immune cells and play a central role in the activation of inflammation and in the first steps of innate immunity against pathogens or tissue damage. Released September 2013.

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Stem Cell Biology

This flyer shows an overview on all AdipoGen stem cell products. AdipoGen focuses especially on Cancer Stem Cell reagents, including markers for metastatic niche (e.g. Periostin), Notch Signaling products and Hedgehog Signaling inhibitors. Released September 2013.

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Innate Immunity - Focus: Inflammasomes & TLR Signaling

The innate immune system plays an essential role in the host’s first line of defense against microbial invasion and involves the recognition of PAMPs or DAMPs by pattern recognition receptors (PRRs). Released August 2013.

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Hedgehog Signaling

The Sonic Hedgehog (Shh) signaling pathway plays key roles in embryonic development, formation and maintenance of cancer stem cells (CSCs) and acquisition of epithelial-to-mesenchymal transition (EMT). Released August 2013.

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Periostin

Periostin is overexpressed in various human tumors and accelerates the development of various tumors by promoting cancer cell survival, epithelial-mesenchymal transition, invasion and metastasis. Released July 2013.

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TNF Superfamily Ligands & Receptors Brochure

TNF Superfamily molecules are expressed in cells of the immune system, and they have been linked to an array of pathophysiologies, including cancer, neurologic diseases, cardiovascular diseases, pulmonary diseases, autoimmune diseases and metabolic diseases. Released July 2013.

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Adiponectin & the CTRP Family

AdfipoGen provides a broad panel of additional adiponectin and CTRP reagents and produces new myokines, which are involved in muscle, exercise & obesity metabolism. Released October 2012.

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ELISA Kits

Includes newly released Irisin Competitive ELISA Kit, Caspase-1 (mouse) ELISA Kit and several new Mateched Pair Detection Sets. Released February 2013.

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Inflammasome Signaling Reagents

This flyer includes a broad range of new Caspase-1 antibodies, all validated on knock-out mice. Released August 2012.

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Cytoskeleton - Focus Microtubules

Microtubules are the largest cytoskeletal components involved in intracellular transport (cell signaling), cell migration/trafficking, cell division and proliferation. Released March 2012.

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ANGPTLs [Angiopoietin-like Proteins]

The ANGPTLs are a group of proteins, each one selectively regulating different processes, such as angiogenesis, several metabolic diseases (obesity, insulin resistance, diabetes), inflammation and stem cell development. Released February 2012.

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Progranulin [PGRN] - A Multifunctional Protein

Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as cancer, development, wound repair, inflammation and it is of high interest for the research on neurodegenerative disease. Released February 2012.

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General Catalog

In this new General Catalog all products are alphabetically listed in 4 sections (ELISA Kits, Antibodies, Proteins and Small Molecules). Released October 2011.

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Ancell

Antibodies Overview

This flyer shows Ancell's extensive panel of human CD antibodies. The products are purified and conjugated under optimized conditions and rigorously tested in cell lines and human samples. Released April 2012.

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Bethyl Laboratories

Primary Antibodies

The 2014 Primary Antibody eCatalog features over 5,000 primary antibody products that have been tested by Western Blot, Immunoprecipitation, Immunofluorescence, Immunohistochemistry, ChIP, Flow Cytometry, ELISA or Proximity Ligation Assay (PLA). Eptiope tag antibodies are also listed. Updated April 2014.

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Secondary Antibodies

The 2014 Secondary Antibody eCatalog features over 1500 antibodies to 27 species, in 6 hosts, and 18 different conjugations. Bethyl utilizes the following conjugates in the secondary antibody manufacturing process: agarose immobilized, alkaline phosphatase, biotin, Cy2™, Cy3™, Cy5™, Cy5.5™, DyLight® 350, DyLight® 488, DyLight® 550, DyLight® 594, DyLight® 650, DyLight® 680, DyLight® 755, DyLight® 800, FITC, Horseradish Peroxidase, and R-Phycoerythrin. Updated April 2014.

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ELISA Kits & Sets

The 2014 ELISA eCatalog features 25 different milk and serum proteins across 10 different species. Bethyl produces complete ELISA kits that include all reagents and supplies required. Bethyl also produces ELISA sets that simply contain an antibody, calibrator and conjugate; the researcher provides all other supplies to complete the assay. Updated April 2014.

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Transcriptional Regulation Antibodies

1400 antibodies targeting over 700 proteins involved with transcriptional regulation. Released February 2014.

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Wnt, Notch, Hedgehog Pathway Antibodies

Bethyl offers over 400 antibodies targeting proteins in the Wnt, Notch and Hedgehog signaling pathways. Released February 2014.

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Innate Immunity Antibodies

Over 200 Antibodies Targeting Innate Immunity Against Viral Infection. Released January 2014.

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Neuroscience Antibodies

Bethyls most popular antibodies targeted toward neuroscience. Released October 2013.

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DyLight Antibody Conjugates

The use of fluorescent probes has become a mainstream technique to detect specific molecular targets in both cell-free and cell-based assays. Released June 2013.

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Biomol GmbH

Cytokines 3.0

The Cytokines Catalog, 3rd Edition. Includes Interleukins, Growth Factors, Interferons, Colony Stimulating Factors, Tumor Necrosis Factors and Chemokines. Released January 2012.

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BPS Bioscience

Catalog 2013

  • Proteins
  • Assay Kits
  • Cell Lines
  • Inhibitors

Released April 2013.

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Cayman Chemical

Currents: Redox Signaling and Thiol Modification

In this Current:

  • Redox Signaling and Thiol Modification
  • Thiol Modification Detection
  • New Product Spotlight: Intracellular O2 Respiratory Burst Imaging Kit
  • Redox Biology

Released October 2014.

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Assay Kits

  • Determining Cell Vitality
  • Screening Mitochondrial Toxicity
  • Assays for 3D Cell Spheroid Cultures
  • Optimizing Protein Stability

Released May 2014.

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Eicosanoids

  • APIs - Prostaglandins with a Purpose
  • EP2 & EP4 - Sibling PGE2 Receptors
  • Hypertension and Eicosanoids
  • Intracellular PLA2 Activation
  • Leukotrienes - Something Old, Something New

Released January 2014.

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Intracellular Signaling

  • Intracellular Signaling to Histone Deacetylases
  • Considering cAMP’s Complexity
  • Phytoestrogen intake and signaling impact
  • Intranuclear Signaling Pathways
  • Oxygen Signaling Through HIF

Released December 2013.

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Epigenetics

  • DNA Methylation
  • Histone Acetylation, Deacetylation, & Genomic Bistability
  • Bromodomains, Chromohub, & STRING
  • Histone Methylation Language of Epigenetics
  • Histone Demethylation

Released June 2013.

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Cancer

  • PGE2, COX-2, and mPGES-1 in Cancer
  • Targeting GPCRs in Cancer
  • Inflammation in Cancer
  • Epigenetics in Cancer as Modeled by EZH2
  • Phospholipase D Signaling in Cancer

Released June 2012.

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Metabolism and Metabolic Disease

  • Targeting PPARβ/δ For Weight Loss: Exercise in a Pill
  • Weight Loss: A New Star is Irisin
  • Sirtuins, to your health
  • The PPARα Story

Released July 2012.

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Oxidative and Nitrosative Stress

  • Radiation Linked to Oxidative Injury
  • Sphingosine-1-Phosphate vs. Ceramide
  • Isoprostanes
  • Nrf2 Antioxidant Stress Response

Released May 2012.

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Receptor Signaling

  • The Many Faces of PI3K
  • Receptors and Tyrosine Kinases
  • G Proteins and Their Coupled Receptors
  • The Wonderful World of Wnt Signaling
  • TLR: Immune Signaling Sentinels

Released May 2012.

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Atherosclerosis

  • Mediating Cholesterol Homeostasis
  • Cholesterol Trafficking
  • Oxidants and Oxidized Phospholipids
  • Macrophage Functions
  • Prostaglandins versus Leukotrienes

Released December 2011.

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Inflammation

  • Bromodomains and Inflammation
  • Lipoxins and Resolvins
  • The Strange Side of Leukotriene Synthesis
  • Citrullination: Much Bigger than Watermelon
  • A Case for mPGES-1 Inhibition and Beyond

Released October 2011.

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Cardiovascular Disease

  • CVD, Pulmonary Hypertension, and Prostacyclins
  • Epigenetics: The New Frontier for Vascular Diseases
  • You Say "Thrombosis", I Say "Thromboxane"
  • eNOS, Vascular Endothelial Health, and CVD

Released October 2011.

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Neuroscience

  • Leukotrienes on the Brain
  • Nitric Oxide Contribution in the CNS: a NO brainer
  • Multiple Sclerosis and Prostaglandin E2 Signaling
  • Alzheimer’s Disease and Arachidonic Acid
  • "Spice" Wars

Released October 2011.

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Chimerigen Laboratories

Chimerigen Product Flyer 2014

Chimiergen develops, manufactures and markets high quality and leading edge proteins for biomedical and immunology research with focus on Immune Checkpoints and Interleukins. Released April 2014.

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Chimerigen Supplement Flyer

Chimerigen's specialty is the production of unique immunoglobulin based chimeric fusion proteins using advanced cellular and molecular biological techniques. Released April 2013.

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Fusion Proteins

The Chimerigen fusion proteins are widely recognized reagents and are cited in many scientific publications. Released April 2012.

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Cytoskeleton

GTPase Activation Assays: Detecting Different Isoforms

Ras and Rho family GTPases are cytoskeletal small G-proteins that critically regulate multiple actin-dependent cell processes, including development, growth, motility, and intracellular trafficking. Moreover, dysfunction of Ras and Rho family GTPases are correlated with several human diseases (e.g., cancer, neurodegeneration) and these GTPases are targeted by multiple pathogenic bacteria. Given the important role that these GTPases have in physiological and pathological processes, the ability to measure the activity of specific Rho and Ras isoforms is paramount. Released November 2014.

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Citrullination: Taking the Charge out of Arg

Protein citrullination (a.k.a. deimination) is a novel argininedirected post-translational modification (PTM) that results in a permanent change in the targeted protein. Peptidylarginine deiminases (PADs) mediate the calcium-dependent deimination of the guanidino group of arginine side chains to form an ureido group and the nonstandard amino acid citrulline. To date, there have been no enzymes identified that can reverse this process. Released October 2014.

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Probing Sub-domains of Kinesin

Recent reports have highlighted a new phase of research for molecular motors. In contrast to five or more years ago, when macromolecular approaches were used, recent research has focused on resolving how kinesin is regulated by intramolecular dynamics. There are two main technical approaches that have allowed measurement of these dynamic mechanisms; these are 1. total internal reflection fluorescence (TIRF) microscopy to observe single kinesin motors and 2. sub-domain swapping from one motor to another. Released September 20014.

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SUMOylation: A Post-translational Modification Targeting Cytoskeletal Proteins

SUMO-mediated regulation of protein localization and function is not only complex but well-positioned as a major regulator of cellular architecture and transport. To better understand how SUMOylation regulates proteins, Cytoskeleton, Inc. is focusing on the development of high-quality antibodies which are highly specific to PTMs. Released August 2014.

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New Inhibitors to Control Ras signaling via Sos/K-Ras Binding

As researchers reveal additional Ras regulatory mechanisms, sensitive and quantitative methods to measure activated levels of these GTPase proteins take on increasing importance. To aid researchers with identifying and characterizing cancer therapeutics, Cytoskeleton, Inc. offers many small G-protein tools such as pull-down and G-LISA activation assays which are widely used to measure the activated levels of small G-proteins. Released July 2014.

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Rho GTPases and Reactive Oxygen Species

Redox agents, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS), are key regulators in a variety of signal transduction pathways.  Rho GTPases are also key regulators of many cellular processes. While redox agents and Rho GTPases operate through a wide array of regulatory mechanisms, crosstalk between ROS/RNS and Rho GTPases is thought to play a pivotal role in many of their physiological functions. Released June 2014.

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Myosin Acetylation Modulates Sarcomere Structure and Function

The importance of acetylation in sarcomere structure and function has recently been elevated by the utilization of histone deacetylase (HDAC) inhibitors in pre-clinical research and the treatment of hypertrophic heart disease, as well as the discovery of several critical acetylated forms of myosin amino acids. Released May 2014.

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Lysine Acetylation - Regulator of Diverse Cellular Processes

Lysine acetylation is a post-translational modification (PTM) crucial for regulating the function and localization of many eukaryotic proteins.  This PTM is reversible, regulated by histone deacetylases (HDACs) and histone acetyltransferases (HATs). Released April 2014.

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Integrin-mediated redox control of beta-actin: PDI's Emergence

Cell migration is an integral part of several biological processes including angiogenesis, wound healing, and immune surveillance.  Integrins are αβ heterodimeric transmembrane receptors that link a cell's dynamic interaction with the extracellular matrix (ECM) to the cytoskeletal rearrangements that are necessary to promote cell motility. Released March 2014.

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Dynein: One Motor, Multiple Neurodegenerative Diseases

Cytoplasmic dynein 1 is a multi-protein complex that serves as the primary ATPhydrolyzing motor responsible for retrograde axonal transport along microtubules in eukaryotic cells. Mutations in dynein (or dynactin) underlie some neurodegenerative diseases in humans, manifested by axonal transport defects, neuron degeneration, locomotor abnormalities, and/or other neural deficits. Released January 2014.

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Minicatalog 2014

  • Actin, Tubulin, Motor and Small G Proteins
  • Activation, ELISA and Pull-down Assays
  • G-LISA Kits
  • Antibodies

Released December 2013.

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Dynein: Hard working, but team oriented

In eukaryote cells, cytoplasmic dynein complex (CDC) and kinesin-14 family members are the only two types of motors known to move cargo to the minus-end of microtubules (MTs). This function is critical for cell metabolism, structure and movement. Released November 2013.

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Neurodegeneration: Rhes, SUMOylation, and Huntington’s Disease

Huntington’s disease is an autosomal dominant neurodegenerative disorder characterized by >35 CAG repeats in the huntingtin gene. Recent research has revealed that the GTPase Rhes may be the key for understanding neurotoxicity in Huntington’s disease. Released October 2013.

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Monoubiquitination: A dynamic tag for protein regulation

  • Monoubiquitination: A Dynamic Tag for Protein Regulation
  • Intramolecular Autoinhibition
  • Intracellular Localization and Trafficking
  • Regulation of Protein Complex Formation

Released September 2013.

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Innaxon

Innaxon - Innate Immunity to Life!

Innaxon develops and manufactures defined “Immunoceuticals” for pre-clinical research and development applications for vaccine adjuvants and immunotherapy. Their unique biological and synthetic Toll-like Receptor (TLR) ligands are well-characterized. Released February 2013.

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Innova Biosciences

Antibody Labeling Brochure

  • Lightning-Link®
  • InnovaCoat® GOLD
  • Thunder-Link®

Released September 2013.

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JaICA

JaICA - Unique Oxidative Stress Markers

The monoclonal antibodies and ELISA kits listed in this brochure detect products of oxidative damage caused by reactive oxygen species. Released February 2013.

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LKT Labs

Neuroscience Research Chemicals

  • Glioma Chemotherapeutics
  • Natural Products
  • Neurotransmitter Modulators
  • Ion Channel Modulators

Released February 2014.

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Catalog 2012-2014

  • Antiangiogenic Compounds
  • Antimicrobials
  • Biologically Active Peptides
  • Natural Products
  • Signal Transduction Chemicals

Released January 2012.

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NewEast Biosciences

Detection of Active G Proteins

Short overview about NewEast Biosciences products for G protein research. The list includes antibodies against active G proteins and G protein activation assay kits. Released December 2013.

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Platypus Technologies

Oris™ Pro Invasion Assay

Cell Invasion Through a Collagen I Matrix:

  • Automation-friendly 96-well assay
  • Real-time and end-point measurements
  • Readout with microscopes & high-content instruments

Released January 2014.

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Oris™ and Oris™ Pro Cell Migration Assays

Oris™ assays employ exclusion zone technology to form centrally located cell-free zones in the centers of cell monolayers. The zones are created by the use of patented silicone stoppers in the Oris™ format and by a proprietary patent-pending biocompatible gel (BCG) in the Oris™ Pro assays. Released April 2013.

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TechNote: Oris™ Cell Migration Assay

Comparison of the Oris™ Cell Migration Assay to the Scratch Assay. Released April 2013.

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ProMab Biotechnologies

Custom Monoclonal Antibodies

Breakdown of the standard custom monoclonal production service offered by ProMab. Released January 2014.

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Rockland Immunochemicals

TrueBlot®

TrueBlot® reagents enable you to generate clear, best-quality data in your immunoprecipitation and western blot protocols. Available in several options, from IP beads, to complete kits for IP/Western Blot, ELISA, or IHC. Released June 2014.

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Cancer - Neuroscience - Epigenetics

List of Rockland antibodies targeted for Cancer, Neuroscience and Epigenetics research. Released April 2013.

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Spring Bioscience

Targeted Products for Cancer Research

Learn more about Spring Biosciences IHC-competent Rabbit Monoclonals (SP Clones) targeted for Cancer Research. Released February 2014.

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Research Catalog 2013

  • Primary Antibodies
  • Detection Systems
  • Antibody Microarrays
  • Recombinant Proteins
  • Complementary Reagents

Released February 2013.

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Detection Technology Flyer

REVEAL™ Biotin-Free IHC Detection System vs. Conventional Polymer Systems. Released March 2011.

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Array Technology Flyer

A brief look on Spring Biosciences Antibody Microarrays. Released March 2011.

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Antibody Technology Flyer

A brief look on SP Clone Rabbit Monoclonal Antibodies. Released March 2011.

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SYNkinase

Kinase Inhibitor Library Arrays

This SYNkinase catalog features high quality, research relevant kinase inhibitor library arrays. Topics include pre-made inhibitor array options, multi-target arrays, pathway and family specific arrays. Released September 2014.

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Kinase Inhibitors

SYNkinase is an original manufacturer of unique, potent and research-relevant inhibitors directed against specific protein serine/threonine kinases (PS/TKs), protein tyrosine kinases (PTK & RTK), lipid kinases and many other targets. In this catalog you will find signalling pathways, a list of compound targets and a list of SYNkinase compounds. Released June 2014.

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