(-)-trans-C75

C75 is stable fatty acid synthase (FASN) inhibitor that when administered in racemic form leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice. C75 is also cytotoxic to many human cancer cell lines, an effect believed to be mediated by the accumulation of malonyl-coenzyme A in cells with an upregulated FASN pathway. (-)-trans-C75 is an enantiomer of C75. Its biologicial activity has not been reported.Formal Name: tetrahydro-4-methylene-2S-octyl-5-oxo-3R-furancarboxylic acid. CAS Number: 1234694-22-4. Synonyms: (2S,3R)-C75. Molecular Formula: C14H22O4. Formula Weight: 254.3. Purity: >97%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 10 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 0.5 mg/ml. SMILES: CCCCCCCC[C@H](OC1=O)[C@H](C(O)=O)C1=C. InChi Code: InChI=1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)/t11-,12?/m0/s1. InChi Key: VCWLZDVWHQVAJU-PXYINDEMSA-N.