tetramethyl Nordihydroguaiaretic Acid

tetramethyl Nordihydroguaiaretic acid is a derivative of the lipoxygenase inhibitor nordihydroguaiaretic acid (Cay-70300). It inhibits Tat-regulated HIV promoter transactivation in COS-1 cells in a reporter assay with an IC50 value of 11 µM and inhibits the replication of acyclovir-sensitive and -resistant strains of herpes simplex virus (HSV-1) in Vero cells in a reporter assay with IC50 values of 5.6 and 8.9 µM, respectively. tetramethyl Nordihydroguaiaretic acid (50 µM) induces cell cycle arrest at the G1/G0 phase in A375 melanoma cells and inhibits tumor growth in an A375 mouse xenograft model when administered at a dose of 250 mg/kg. tetramethyl Nordihydroguaiaretic acid (166 mg/kg) also reduces tumor growth in a B16 murine melanoma model.Formal Name: rel-4-[(2R,3S)-4-(3,4-dimethoxyphenyl)-2,3-dimethylbutyl]-1,2-dimethoxy-benzene. CAS Number: 24150-24-1. Synonyms: EM-1421, M4N, Tetrameprocol, tetramethyl NDGA, TMNDGA. Molecular Formula: C22H30O4. Formula Weight: 358.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2.5 mg/ml, DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml, DMSO: 2 mg/ml, Ethanol: 0.2 mg/ml. lambdamax: 230, 280 nm. SMILES: COc1cc(ccc1OC)CC(C)C(C)Cc1ccc(OC)c(OC)c1. InChi Code: InChI=1S/C22H30O4/c1-15(11-17-7-9-19(23-3)21(13-17)25-5)16(2)12-18-8-10-20(24-4)22(14-18)26-6/h7-10,13-16H,11-12H2,1-6H3/t15-,16+. InChi Key: ORQFDHFZSMXRLM-IYBDPMFKSA-N.