sFas Receptor, human recombinant (rHuFAS)

sFas Receptor, human recombinant (rHuFAS)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
97567.5 5 µg - -

3 - 10 business days*

94.00€
97567.20 20 µg - -

3 - 10 business days*

208.00€
97567.1 1 mg - -

3 - 10 business days*

5,242.00€
 
Human recombinant sFas Receptor produced in E.coli is a single, non-glycosylated polypeptide... more
Product information "sFas Receptor, human recombinant (rHuFAS)"
Human recombinant sFas Receptor produced in E.coli is a single, non-glycosylated polypeptide chain containing 157 amino acids and having a molecular mass of 17.6kDa. Fas and Fas Ligand (FasL) are members of the TNF superfamily and are type I and type II transmembrane proteins, respectively. Binding of FasL to Fas initiates apoptosis in Fas-bearing cells. The apoptosis mechanism involves the recruitment of pro-caspase 8 through an adaptor molecule named FADD followed by processing of the pro-enzyme to active forms. These active caspases subsequently cleave a variety of cellular substrates leading to the eventual cell death. sFasR is able to inhibit FasL-induced apoptosis by acting as a decoy receptor whicht serves as a sink for FasL. The full length Fas Receptor is a 319 amino acids type I transmembrane protein, which contains a 157 amino acids extracellular domain, a 17 amino aicds transmembrane domain, and 145 amino acids cytoplasmic domain. The mature human Fas ECD shares 55%, 58%, a.a sequence identity with the mouse, rat, Fas, respectively.
Keywords: Tumor necrosis factor receptor superfamily member 6, Apo-1 antigen, Apoptosis-mediating surface antigen FAS, FASLG receptor, CD95, FAS, APT1, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6.
Supplier: Biomol GmbH
Supplier-Nr: 97567

Properties

Application: Cell Culture
Conjugate: No
Host: E.coli
Species reactivity: human
MW: 17.6 kD
Purity: >95%
Format: Lyophilized

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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