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The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis. In addition to p53, mammalian cells contain two p53 family members, p63 and p73, which are similar to p53 in both...

The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis (1). In addition to p53, mammalian cells contain two p53 family members, p63 and p73, which are similar to p53 in...

Neutrophil cytosolic factor 1 (NCF1) is a 47kD cytosolic subunit of the multi-protein complex known as NADPH oxidase. Expression of NCF1 is restricted to granulocytes, monocytes and B lymphocytes. Defects in NCF1 have been reported to be a cause of autosomal recessive chronic granulomatous disease. Applications:...

p53 is an intensively studied tumor suppressor protein, which has a vital role in the control of cell growth. In normal circumstances cells arrest during the G1/G2 phase of the cell cycle, and undertake any DNA repair processes that are necessary. This arrest is mediated by p53, and if p53 is absent or damaged cells...

Location:, 15 amino acids near the amino terminus of human p53AIP, Applications: Peptide is used for blocking the activity of p53AIP antibody (P1001-32V3). It usually blocks the antibody activity completely in Western Blot by incubating the peptide with equal volume of antibody for 30 min at 37?C. Buffer is PBS...

Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding...

The tumor suppressor p53 is a critical mediator of cellular responses to DNA damage. p53 stability and transcriptional activity are modulated by post-translational modifications such as phosphorylation and acetylation. In response to UV or gamma irradiation, the p53 tetramerization domain becomes a target for...

The p53 tumor antigen is found in increased amounts in a wide variety of transformed cells. The protein is also detectable in many actively proliferating, nontransformed cells, but it is undetectable or present at low levels in resting cells. This protein induces cell cycle arrest or apoptosis in response to...

The p53 tumor antigen is found in increased amounts in a wide variety of transformed cells. The protein is also detectable in many actively proliferating, nontransformed cells, but it is undetectable or present at low levels in resting cells. This protein induces cell cycle arrest or apoptosis in response to...

The p53 tumor antigen is found in increased amounts in a wide variety of transformed cells. The protein is also detectable in many actively proliferating, nontransformed cells, but it is undetectable or present at low levels in resting cells. This protein induces cell cycle arrest or apoptosis in response to...

The p53 tumor antigen is found in increased amounts in a wide variety of transformed cells. The protein is also detectable in many actively proliferating, nontransformed cells, but it is undetectable or present at low levels in resting cells. This protein induces cell cycle arrest or apoptosis in response to...

Sequence:, NH2-MFQRLNKMFVGEVS-COOH , Location: aa1-14 of human p53DINP1 (1). Applications: The peptide is used for blocking the antibody activity of p53DINP1. It usually blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37°C. Storage and...