p-nitro-Pifithrin-alpha

Pifithrin-alpha (Cay-13326) is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis. p-nitro-Pifithrin-alpha is a cell-permeable analog of pifithrin-alpha. It blocks p53-mediated expression of p21/WAF1 and apoptosis in cortical neurons ten-fold more potently than pifithrin-alpha. p-nitro-Pifithrin-alpha, at 10 µM, suppresses p53-mediated TGF-beta1 expression in human proximal tubular cells and attenuates steatosis and liver injury in mice fed a high-fat diet. It is slowly converted into a more potent cyclized form, p-nitro cyclic pifithrin-alpha, when incubated in biological media (t½ = 8 h).Formal Name: 1-(4-nitrophenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)-ethanone, monohydrobromide. CAS Number: 389850-21-9. Synonyms: p-nitro-PFT-alpha. Molecular Formula: C15H15N3O3S . HBr. Formula Weight: 398.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml. lambdamax: 263 nm. SMILES: N=C(S1)N(CC(C2=CC=C([N+]([O-])=O)C=C2)=O)C3=C1CCCC3.Br. InChi Code: InChI=1S/C15H15N3O3S.BrH/c16-15-17(12-3-1-2-4-14(12)22-15)9-13(19)10-5-7-11(8-6-10)18(20)21,/h5-8,16H,1-4,9H2,1H. InChi Key: NXPCMOGORSWOLH-UHFFFAOYSA-N.