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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
AG-40B-0069-C010 | 10 µg | - |
3 - 9 business days* |
193.00€
|
|||
AG-40B-0069-5010 | 50 µg (5 x 10 µg) | - |
3 - 9 business days* |
578.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
(5 x 10µg). The extracellular domain of human TRAIL (amino acids 95-281) is fused at the... more
Product information "izTRAIL, Soluble (human, rec.)"
(5 x 10µg). The extracellular domain of human TRAIL (amino acids 95-281) is fused at the N-terminus to an isoleucine zipper motif. Induces apoptosis in vitro in different human cancer cell lines with an EC50 of 5-200ng/ml, depending on the individual cell line used. Recombinant izTRAIL does not kill 4-day cultures of primary human hepatocytes (PHH) at concentrations of at least up to 1µg/ml (Ganten 2006). Good bioavailability in vivo, shows no toxic effects in mice at doses of at least up to 500µg per day (Wissink 2006). Lyophilized. Contains 20mM TRIS-Cl, 0.5M arginine-HCl, 100mM NaCl, 0.02% Tween 20. izTRAIL is a newly available, highly active recombinant form of soluble human TRAIL. Due to a trimerizing N-terminal isoleucine zipper (iz) motif the intrinsic trimerization of TRAIL, required for apoptosis-inducing activity of TRAIL, is enhanced when compared to non-tagged soluble human TRAIL (shTRAIL). Therefore, izTRAIL is a potent inducer of apoptosis in many human cancer cells, but not normal human hepatocytes. In addition, the half-life of izTRAIL is about eight-fold higher than the half-life of shTRAIL. These properties render izTRAIL highly suitable for both, in vitro and in vivo use, particularly for studies in which investigators plan to transfer their in vitro results into an in vivo system with human cancer cells in xenotransplant settings examining susceptibility to TRAIL-induced apoptosis.
Keywords: | Apo-2L, TNFSF10, CD253 |
Supplier: | AdipoGen Life Sciences |
Supplier-Nr: | AG-40B-0069 |
Properties
Application: | Bioassays |
Conjugate: | No |
Host: | E.coli |
Species reactivity: | human |
MW: | 82 kD |
Format: | Lyophilized |
Database Information
KEGG ID : | K04721 | Matching products |
UniProt ID : | P50591 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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