Ziprasidone (hydrochloride hydrate)

Ziprasidone (hydrochloride hydrate)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay15031-5 5 mg -

6 - 10 business days*

60.00€
Cay15031-10 10 mg -

6 - 10 business days*

105.00€
Cay15031-25 25 mg -

6 - 10 business days*

230.00€
Cay15031-50 50 mg -

6 - 10 business days*

259.00€
 
Ziprasidone is an atypical antipsychotic. It is an agonist of the serotonin (5-HT) receptor... more
Product information "Ziprasidone (hydrochloride hydrate)"
Ziprasidone is an atypical antipsychotic. It is an agonist of the serotonin (5-HT) receptor subtype 5-HT1A (EC50 = 36.31 nM for inhibition of forskolin-induced adenylate cyclase activity in HeLa cells expressing human receptors), as well as an inverse agonist of 5-HT1D receptors (IC50 = 2.69 nM) and a partial agonist of 5-HT1B receptors (EC50 = 6.17 nM) in [35S]GTPgammaS binding assays. Ziprasidone is an antagonist at 5-HT2A and dopamine D2 receptors (Kis = 1.15 and 1.29 nM, respectively) in cell-based assays. It inhibits d-amphetamine-induced hyperactivity and apomorphine-induced stereotypy in rats (ID50s = 1.53 and 2.43 mg/kg, respectively). Formulations containing ziprasidone have been used in the treatment of schizophrenia and bipolar I disorder.Formal Name: 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one, monohydrochloride, monohydrate. CAS Number: 138982-67-9. Synonyms: CP 88,059. Molecular Formula: C21H21ClN4OS . HCl [H2O]. Formula Weight: 467.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.16 mg/ml, DMSO: 1.2 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml. lambdamax: 211, 314 nm. SMILES: O=C1CC2=CC(CCN3CCN(C4=NSC5=C4C=CC=C5)CC3)=C(Cl)C=C2N1.Cl.O. InChi Code: InChI=1S/C21H21ClN4OS.ClH.H2O/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21,,/h1-4,11,13H,5-10,12H2,(H,23,27),1H,1H2. InChi Key: ZCBZSCBNOOIHFP-UHFFFAOYSA-N.
Keywords: CP-88,059, 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one, monohydrochloride, monohydrate
Supplier: Cayman Chemical
Supplier-Nr: 15031

Properties

Application: Serotonin 5-HT2A and dopamine D2 antagonist, 5-HT1A receptor agonist
MW: 467.4 D
Formula: C21H21ClN4OS . HCl [H2O]
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 138982-67-9| Matching products
KEGG ID : K04145 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H317, H373
P Phrases: P260, P261, P272, P280, P314, P321, P302+P352, P333+P313, P362+P364, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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