ZM 447439

ZM 447439
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13601-5 5 mg -

6 - 10 business days*

82.00€
Cay13601-10 10 mg -

6 - 10 business days*

143.00€
Cay13601-50 50 mg -

6 - 10 business days*

471.00€
 
The Aurora kinases have important roles in regulating mitosis and cytokinesis, with Aurora B... more
Product information "ZM 447439"
The Aurora kinases have important roles in regulating mitosis and cytokinesis, with Aurora B involved in centromere function as part of the Chromosomal Passenger Complex, with survivin, INCENP, and borealin. ZM 447439 is a selective inhibitor of Aurora B kinase (IC50 = 50 nM), less potently inhibiting Aurora C and A (IC50 = 250 and 1,000 nM, respectively). It has no effect on several other kinases, including Cdk1, Cdk2, Cdk4, Plk1, CHK1, KDR2, and FAK (IC50 > 10 µM). ZM 447439 has been used to study the role of Aurora B in molecular events associated with mitosis and cytokinesis. Moreover, ZM 447439 selectively inhibits proliferating cells rather than non-dividing cells, suggesting its potential in cancer therapy.Formal Name: N-[4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]-benzamide. CAS Number: 331771-20-1. Molecular Formula: C29H31N5O4. Formula Weight: 513.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml. lambdamax: 226, 252, 343 nm. SMILES: COC1=C(C=C(N=CN=C2NC3=CC=C(NC(C4=CC=CC=C4)=O)C=C3)C2=C1)OCCCN5CCOCC5. InChi Code: InChI=1S/C29H31N5O4/c1-36-26-18-24-25(19-27(26)38-15-5-12-34-13-16-37-17-14-34)30-20-31-28(24)32-22-8-10-23(11-9-22)33-29(35)21-6-3-2-4-7-21/h2-4,6-11,18-20H,5,12-17H2,1H3,(H,33,35)(H,30,31,32). InChi Key: OGNYUTNQZVRGMN-UHFFFAOYSA-N.
Keywords: N-[4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]-benzamide
Supplier: Cayman Chemical
Supplier-Nr: 13601

Properties

Application: Aurora B kinase inhibitor
MW: 513.6 D
Formula: C29H31N5O4
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 331771-20-1| Matching products
KEGG ID : K11479 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H301
P Phrases: P264, P270, P301+310, P321, P330, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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