YS-121

YS-121
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13665-1 1 mg -

6 - 10 business days*

74.00€
Cay13665-5 5 mg -

6 - 10 business days*

316.00€
Cay13665-10 10 mg -

6 - 10 business days*

563.00€
Cay13665-25 25 mg -

6 - 10 business days*

1,224.00€
 
Microsomal prostaglandin E2 synthase-1 (mPGES-1), with cyclooxygenase-2 (COX-2), synthesizes... more
Product information "YS-121"
Microsomal prostaglandin E2 synthase-1 (mPGES-1), with cyclooxygenase-2 (COX-2), synthesizes PGE2, which is directly involved in signaling during inflammation, fever, and pain. 5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs), which are pro-inflammatory mediators. YS-121 is a dual inhibitor of mPGES-1 (IC50 = 3.9 µM) and 5-LO (IC50 = 4.1 µM). It effectively inhibits PGE2 and LT synthesis in both cell free and intact cell assays. Moreover, YS-121 (1.5 mg/kg, intraperitoneal) reduced pleural levels of PGE2 and LTB4 while blocking exudate formation and leukocyte infiltration in carrageenan-induced rat pleurisy. YS-121 has minor effects on COX-1 and COX-2, inhibiting these enzymes 24.8% and 38%, respectively, at 10 µM.Formal Name: 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-octanoic acid. CAS Number: 916482-17-2. Molecular Formula: C20H26ClN3O2S. Formula Weight: 408.0. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 203, 246, 292 nm. SMILES: CC1=C(NC2=CC(Cl)=NC(SC(C(O)=O)CCCCCC)=N2)C=CC=C1C. InChi Code: InChI=1S/C20H26ClN3O2S/c1-4-5-6-7-11-16(19(25)26)27-20-23-17(21)12-18(24-20)22-15-10-8-9-13(2)14(15)3/h8-10,12,16H,4-7,11H2,1-3H3,(H,25,26)(H,22,23,24). InChi Key: HVJBWTVMRIOTEL-UHFFFAOYSA-N.
Keywords: 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-octanoic acid
Supplier: Cayman Chemical
Supplier-Nr: 13665

Properties

Application: mPGES-1/5-LO inhibitor
MW: 408 D
Formula: C20H26ClN3O2S
Purity: >98%
Format: Solution

Database Information

CAS : 916482-17-2| Matching products
KEGG ID : K00461 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H319, H333, H336
P Phrases: P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+361+353, P304+312, P304+340, P305+351+338, P312, P337+313, P370+378, P403+233, P403+235, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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