6 products were found matching "Cay16495"!

X-Gal is a chromogenic substrate for beta-galactosidase. Upon cleavage by beta-galactosidase, a blue pigment is released that can be used as a marker of beta-galactosidase activity. X-Gal has been used for the detection of lacZ activity in reporter assays and in the determination of protein-protein...

TNP-470 is a synthetic analog of fumagillin (Cay-11332) that inhibits angiogenesis. It irreversibly inactivates methionine aminopeptidase-2 (MetAP2, IC50 = 2 µM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo. It is without effect on MetAP1. TNP-470 has therapeutic potential in cancer and...

Three related forms of the kinase Akt (1, 2, 3, also known as protein kinase B isoforms PKBalpha, beta, gamma) modulate cell proliferation, metabolism, and survival as well as angiogenesis. A-443654 is an inhibitor of Akt (Ki = 160 pmol/L for all three isoforms) that interferes with mitotic progression and bipolar...

n-Dodecyl-beta-D-maltoside (DDM) is a non-ionic detergent commonly used to solubilize membrane-associated proteins. In particular, it helps retain the native conformation and activity of membrane-associated proteins, and facilitates the reforming of these proteins after denaturation. The critical micelle...

Isorhamnetin is a natural flavonol aglycone that is the 3-methyl metabolite of quercetin (Cay-10005169). It has antioxidant activity and inhibits xanthine oxidase (IC50 = 0.40 µM). Isorhamnetin also competitively inhibits the human multidrug and toxic compounds extrusion transporter 1 (Ki = 0.32 µM), which has an...

Glycopyrrolate is an antagonist of muscarinic acetylcholine receptors (mAChRs, Kis = 0.42, 1.77, 0.52, 0.78, and 1.29 nM for the M1-M5 receptors, respectively). It induces relaxation of precontracted isolated human bronchi when used at concentrations of 0.01, 0.1, or 1 µM. Glycopyrrolate reduces post-prandial...