4 products were found matching "Cay13767-1"!

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113-O12B
113-O12B

Item number: Cay37671-10

113-O12B is a disulfide bond-containing ionizable cationic lipidoid. It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA. Subcutaneous administration of LNPs containing 113-O12B and encapsulating an mRNA reporter accumulate specifically in mouse lymph nodes. LNPs containing...
Keywords: tetrakis(2-(octyldisulfaneyl)ethyl) 3,3',3'',3'''-(((methylazanediyl)bis(ethane-2,1-diyl))bis(azanetriyl))tetrapropionate
Application: Cationic lipidoid, LNP generation
CAS 2803699-72-9
MW: 1223 D
From 159.00€ *
Review
AMG 706
AMG 706

Item number: Cay17671-1

AMG 706 is a multikinase inhibitor that predominantly targets receptor tyrosine kinases, including VEGFR1, VEGFR2, VEGFR3, c-Kit, PDGFR, and RET (IC50s = 2, 3, 6, 8, 84, and 59 nM, respectively). It also potently inhibits CSF1R and ZAK (IC50s = 5.6 and 8 nM, respectively), as well as several mutants of c-Kit. AMG...
Keywords: Motesanib, N-(2,3-dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide, diphosphate
Application: Flk-1 / Flt-4 / PDGFR-beta / c-Kit inhibitor
CAS 857876-30-3
MW: 569.4 D
From 60.00€ *
Review
Wortmannin-Rapamycin Conjugate
Wortmannin-Rapamycin Conjugate

Item number: Cay13671-1

Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) act synergistically in promoting cancer. Wortmannin is a potent inhibitor of PI3K enzymes, while rapamycin blocks mTOR Complex 1 TORC1. Wortmannin-rapamycin conjugate consists of analogs of 17-hydroxy wortmannin and rapamycin conjugated via a...
Keywords: 1-(4S,4aR,5R,6aS,7S,9aR,E)-1-(((3-(dimethylamino)propyl)(methyl)amino)methylene)-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-di...
Application: PI3K/TORC1 inhibitors
CAS 1067892-47-0
MW: 1598.9 D
From 204.00€ *
Review
GSK2606414
GSK2606414

Item number: Cay17376-5

GSK2606414 is an orally available, selective protein kinase R-like ER kinase (PERK) inhibitor with an IC50 value of 0.4 nM. It can inhibit thapsigargin-induced PERK phosphorylation in lung carcinoma A549 cells and attenuates subcutaneous pancreatic human tumor xenograft growth in mice. Because PERK mediates the...
Keywords: 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-(trifluoromethyl)phenyl]-ethanone
Application: EIF2AK3?/ PERK inhibitor
CAS 1337531-36-8
MW: 451.4 D
From 48.00€ *
Review