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Item number: CAY10009109-1

W146 is a sphingosine-1-phosphate receptor 1 (S1P1) antagonist (Ki = 77 nM). It is selective for S1P1 over S1P2, S1P3, and S1P5 receptors (Kis = >10 µM for all). W146 prevents ligand-induced receptor internalization in CHO cells and inhibits the phosphorylation of ERK1 and Akt when used at a concentration of 10 µM....

Keywords:	[3R-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid, mono(trifluoroacetate)
Application:	S1P1 receptor antagonist
CAS	909725-62-8
MW:	456.4 D

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