Vincristine (sulfate)

Vincristine (sulfate)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay11764-5 5 mg -

6 - 10 business days*

54.00€
Cay11764-10 10 mg -

6 - 10 business days*

102.00€
Cay11764-25 25 mg -

6 - 10 business days*

237.00€
 
Vincristine is an antimitotic vinca alkaloid, isolated from the plant V. rosea. It irreversibly... more
Product information "Vincristine (sulfate)"
Vincristine is an antimitotic vinca alkaloid, isolated from the plant V. rosea. It irreversibly blocks mitosis by binding to tubulin (Ki = 85 nM) and inhibiting tubulin polymerization. Vincristine is exported from cells via the ATP-binding cassette transporter P-glycoprotein, but not by multidrug resistance-associated protein. Its effectiveness in blocking the proliferation of cancer cells is affected by overexpression of P-glycoprotein.Formal Name: 22-oxo-vincaleukoblastine sulfate. CAS Number: 2068-78-2. Synonyms: Kyocristine, Lilly 37231, Leurocristine, Novopharm, NSC 67574, Oncovin, VCR. Molecular Formula: C46H56N4O10 . H2SO4. Formula Weight: 923.0. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMSO: 5 mg/ml, PBS (pH 7.2): 2 mg/ml. lambdamax: 221, 259, 296 nm. SMILES: CC[C@]1(O)C[C@@](C[N@@](CC2)C1)([H])C[C@](C(OC)=O)(C3=C(OC)C=C(N(C)[C@]4([H])[C@@]56[C@](N7CC6)([H])[C@](C=CC7)(CC)[C@@H](OC(C)=O)[C@]4(O)C(OC)=O)C5=C3)C8=C2C(C=CC=C9)=C9N8.O=S(O)(O)=O. InChi Code: InChI=1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6,1-5(2,3)4/h9-13,15,20-21. InChi Key: AQTQHPDCURKLKT-PNYVAJAMSA-N. Origin: Plant/Vinca rosea.
Keywords: Kyocristine, Leurocristine, Lilly 37231, Novopharm, NSC 67574, Oncovin, VCR, 22-oxo-vincaleukoblastine sulfate
Supplier: Cayman Chemical
Supplier-Nr: 11764

Properties

Application: Cancer studies
MW: 923 D
Formula: C46H56N4O10 . H2SO4
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 2068-78-2| Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H300, H341, H361
P Phrases: P201, P202, P264, P270, P280, P301+310, P308+313, P321, P330, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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