Vincristine is an antimitotic vinca alkaloid, isolated from the plant V. rosea. It irreversibly blocks mitosis by binding to tubulin (Ki = 85 nM) and inhibiting tubulin polymerization. Vincristine is exported from cells via the ATP-binding cassette transporter P-glycoprotein, but not by multidrug...

NADPH oxidase 1 (NOX1) and NOX4 generate reactive oxygen species (ROS) that are critical in regulating a variety of cellular functions but also contribute to many diseases. GKT137831 is a dual inhibitor of both NOX1 and NOX4 with Ki values in the range of 100 to 150 nM in cell-free assays of ROS production. It shows...

Amylose is a polysaccharide made of alpha-D-glucose units, bound to each other through alpha(1->4) glycosidic bonds. It constitutes about 20% of starch, the major storage carbohydrate in plants. It can act as an indicator, turning blue in the presence of iodine, and has also been coupled to magnetic beads for the...

1,2-Diamino-4,5-dimethoxybenzene is an aromatic diamine that reacts with aldehydes to produce highly fluorescent benzimidazole derivatives with excitation/emission spectra of 361/448 nm. It can be reacted with ketones and carbonyls, including stress compounds such as glyoxal and methylglyoxal, to form fluorescent...