- Search results for Cay11351
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7 products were found matching "Cay11351"!
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Item number: Cay11351-5
Verruculogen is a tremorgenic mycotoxin isolated from species of Penicillium, Aspergillus, and other fungi. It selectively inhibits the activation of large-conductance calcium-activated potassium channels (KCa1.1/BK) potassium channels by charybdotoxin with a K1/2 value of 170 nM. Verruculogen also promotes the...
Keywords: | NA 209A, TR 1,... |
Application: | Inhibitor of BK channel activation by charybdotoxin |
CAS | 12771-72-1 |
MW: | 511.6 D |
From 134.00€
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Item number: Cay13355-1
Geldanamycin is a benzoquinone ansamycin antibiotic which binds heat shock protein 90 (Hsp90) and its paralog GRP94, altering their actions. Through its interaction with these chaperones, geldanamycin indirectly affects numerous client proteins with roles in diverse cellular processes, including gene expression,...
Keywords: | NSC 122750,... |
Application: | Antibiotic |
CAS | 30562-34-6 |
MW: | 560.6 D |
From 77.00€
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Item number: Cay13335-1
SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that blocks phosphorylation of cdc25 with an IC50 value of 15 nM. It less potently inhibits cdc2 and PKC (IC50s = 250 and 1,000 nM, respectively) and causes 85% inhibition of PKD1 at 1 µM. SB 218078 releases G2 cell cycle arrest induced by gamma-irradiation or...
Keywords: | 9,10,11,12-tetrahydro-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione |
Application: | Chk1 inhibitor |
CAS | 135897-06-2 |
MW: | 393.4 D |
189.00€
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Item number: Cay13351-1
Myristic acid is a 14-carbon saturated fatty acid. It is incorporated into myristoyl coenzyme A (myristoyl-CoA) and transferred by N-myristoyltransferase to the N-terminal glycine of certain proteins either during translation to modify protein activity or post-translationally in apoptotic cells.Formal Name:...
Keywords: | C14:0, NSC 5028, tetradecanoic acid |
Application: | N-myristoylation |
CAS | 544-63-8 |
MW: | 228.4 D |
From 20.00€
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Item number: Cay13511-1
1-Deoxysphinganine is an atypical sphingolipid that lacks the C1-hydroxyl group of canonical sphinganine and is formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis. Plasma levels of 1-deoxysphinganine are increased in patients with hereditary...
Keywords: | 1-deoxySA, ES-285, Spisulosine, 2S-amino-3R-octadecanol |
Application: | Atypical sphingolipid |
CAS | 196497-48-0 |
MW: | 285.5 D |
From 158.00€
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Item number: Cay11350-1
Thiolutin is a natural dithiol that reversibly inhibits bacterial and yeast RNA polymerases (IC50 = 3 µg/ml). Because of this, it can be used for the analysis of mRNA stability. Thiolutin also inhibits endothelial cell adhesion (IC50 induced angiogenesis in mice by inhibiting Hsp27 interactions with cytoskeletal...
Keywords: | Acetopyrrothin, NSC 3927, N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)-acetamide |
Application: | RNA polymerase inhibitor |
CAS | 87-11-6 |
MW: | 228.3 D |
From 104.00€
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Item number: Cay11352-1
Withaferin A is a steroidal lactone that has been found in W. somnifera with diverse biological activities. It binds to and induces aggregation of vimentin intermediate filaments in cultured endothelial cells and fibroblasts, inducing apoptosis when used at concentrations ranging from 2 to 25 µM. It also induces...
Keywords: | NSC 101088, NSC 273757, 5beta,6beta-epoxy-4beta,22R,27-trihydroxy-1-oxo-delta-lactone-ergosta-2,24-dien-26-oic acid |
Application: | Apoptosis inducer, Angiogenesis inhibitor |
CAS | 5119-48-2 |
MW: | 470.6 D |
From 109.00€
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