Valproic Acid (sodium salt)

Valproic Acid (sodium salt)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13033-10 10 g -

6 - 10 business days*

50.00€
Cay13033-25 25 g -

6 - 10 business days*

90.00€
Cay13033-50 50 g -

6 - 10 business days*

156.00€
Cay13033-100 100 g -

6 - 10 business days*

262.00€
 
Valproic acid is an analog of the natural fatty acid valeric acid that inhibits class I histone... more
Product information "Valproic Acid (sodium salt)"
Valproic acid is an analog of the natural fatty acid valeric acid that inhibits class I histone deacetylases (HDACs) with an IC50 value of approximately 2 mM. It decreases the number of axon branches in sensory neurons isolated from newborn rat dorsal root ganglia, an effect that is reversed by inositol-1,4,5-trisphosphate (1,4,5-IP3). In vivo, valproic acid inhibits amyloid-beta deposition and neuritic plaque formation and decreases escape latency in Morris water maze, indicating improved memory performance, in the APP23 transgenic mouse model of Alzheimer's disease. Valproic acid has anticonvulsant activity in the pentylenetetrazol seizure threshold test in mice (ED50 = 0.71 mmol/kg) but induces neurotoxicity when administered at doses greater than or equal to 1.2 mmol/kg. Formulations containing valproic acid have been used in the treatment of bipolar disorder and various seizure disorders.Formal Name: 2-propyl-pentanoic acid, monosodium salt. CAS Number: 1069-66-5. Synonyms: 2-Propylvaleric Acid, Valproate, VPA. Molecular Formula: C8H15O2 . Na. Formula Weight: 166.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: CCCC(CCC)C([O-])=O.[Na+]. InChi Code: InChI=1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10,/h7H,3-6H2,1-2H3,(H,9,10),/q,+1/p-1. InChi Key: AEQFSUDEHCCHBT-UHFFFAOYSA-M. Origin: Synthetic.
Keywords: 2-Propylvaleric Acid, Valproate, VPA, 2-propyl-pentanoic acid, monosodium salt
Supplier: Cayman Chemical
Supplier-Nr: 13033

Properties

Application: HDAC inhibitor
MW: 166.2 D
Formula: C8H15O2 . Na
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 1069-66-5| Matching products
KEGG ID : K06067 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H302, H315, H319, H335, H360
P Phrases: P201, P202, P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P308+313, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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