19 products were found matching "SYN-1123-M100"!

Solid. Soluble in DMSO. Orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathways, with potential antineoplastic activity. Specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation...

Soluble in DMSO. S6K-18 is a highly selective inhibitor of S6K1, with an IC(50) of 52nM. Target: S6K , Kinase Group: AGC , Substrate: Serine-Threonine

Solid. Soluble in DMSO. Insoluble in water. Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an...

Soluble in DMSO or ethanol. TG101209 is a potent, small molecule JAK2-selective kinase inhibitor with IC(50) values of 6, 25, 17 and 169nM for JAK2, FLT3, RET and JAK3. Target: JAK2 , Kinase Group: PTK , Substrate: Tyrosine

Slightly soluble (<1mg/ml) in DMSO or ethanol. Tamatinib effectively inhibits BCR signaling in vivo, resulting in reduced proliferation and survival of the malignant B cells and significantly prolonged survival of the treated animals. Target: BCR , Kinase Group: PTK , Substrate: Tyrosine

Soluble in DMSO. AMG-25 exhibits potent inhibition of c-Kit with greater than 200-fold selectivity over KDR, p38, Lck and Src.

Soluble in DMSO. AMG-1 is a potent inhibitor of human c-Met and RON with IC(50) values of 4 and 9nM respectively. Target: c-Met - RON , Kinase Group: RTK , Substrate: Tyrosine

Soluble in DMSO or ethanol. SCH900776 is a selective Chk1 inhibitor with an IC(50) of 3nM. It shows 50-fold selectivity for Chk1 versus Chk2. Target: Chk1 , Kinase Group: CAMK , Substrate: Serine-Threonine

Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol. GSK2126458 is an orally available selective inhibitor of the class I phosphoinositide 3-kinase (PI3K) enzymes and MTOR1/2 complexes. GSK2126458 can inhibit PI3K-alpha (p85alpha/p110alpha) with IC(50) of 0.04nM. GSK2126458 has Ki values in the picomolar range...

Soluble in DMSO. JNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with an IC(50) of 40nM. It also inhibits closely related tyrosine kinases such as Ret (IC(50) of 180nM) and Kit (C50 of 500nM). It has no significant activity (>1µM) against VEGFR-1 and VEGFR-3. Target: VEGFR-2 ,...

Soluble in DMSO or ethanol. TAK-285 is a novel investigational dual HER2/EGFR inhibitor with IC(50) values of 17 and 23nM, respectively. Target: EGFR - HER2 , Kinase Group: RTK , Substrate: Tyrosine

Soluble in DMSO or ethanol. R406 is a strong Syk inhibitor with an IC(50) of 41nM. It inhibits Syk but not Lyn. It shows 5-fold less potency to Flt3. Target: Syk , Kinase Group: PTK , Substrate: Tyrosine