VER-49009

The heat shock proteins (Hsps) act as molecular chaperones. Hsp90 is an abundant protein with roles in protein folding, cell signaling, and cancer. VER-49009 is a pyrazole compound that inhibits Hsp90 with an IC50 value of 47 nM. It produces a cellular antiproliferative GI50 value of 685 nM when tested against a human cancer cell line panel. Consistent with inhibition of Hsp90, VER-49009 induces the expression of Hsp27 and Hsp72 while reducing the client proteins c-Raf, B-Raf, survivin, and PRMT5, causing cell cycle arrest and apoptosis.Formal Name: 3-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide. CAS Number: 558640-51-0. Molecular Formula: C19H18ClN3O4. Formula Weight: 387.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. SMILES: ClC1=C(O)C=C(O)C(C2=NNC(C(NCC)=O)=C2C3=CC=C(OC)C=C3)=C1. InChi Code: InChI=1S/C19H18ClN3O4/c1-3-21-19(26)18-16(10-4-6-11(27-2)7-5-10)17(22-23-18)12-8-13(20)15(25)9-14(12)24/h4-9,24-25H,3H2,1-2H3,(H,21,26)(H,22,23). InChi Key: HUNAOTXNHVALTN-UHFFFAOYSA-N.