Nitrogenous base on RNA nucleosides. Synonyms: 2,4-Dihydroxypyrimidine, 2,4-Dioxopyrimidine, 2,4-Pyrimidinediol, 2,4(1H,3H)-Pyrimidinedione, 2,4-Pyrimidinedione, 4-Hydroxyuracil, Hybar X, NSC 3970, Pirod, Pyrod, CAS No: 66-22-8, Molecular Formula: C?H?N?O?, Molecular Weight: 112.09, Appearance: White to off-white...

Catalyzes the hydrolysis of N-glycosylic bond between the uracil and sugar, leaving an apyrimidinic site in uracil-containing single or double-stranded DNA. It shows no activity on RNA (1). Unit Definition: 1unit of Uracil DNA Glycosylase catalyses the release of 1nanomole of uracil from uacil containing DNA...

The human UNG-gene encodes nuclear (UNG2) and mitochondrial (UNG1) forms of uracil-DNA glycosylase using differentially regulated promoters, PA and PB, and alternative splicing to produce two proteins with unique N-terminal sorting sequences. A major role of the UNG gene product(s) is to repair mutagenic U:G...

The human UNG gene encodes both mitochondrial (UNG1) and nuclear (UNG2) forms of uracil-DNA glycosylase (UNG). These forms are generated from transcription from alternative promoters, promoter A and promoter B respectively, and the subsequent use of alternative splicing. UNG is responsible for the removal of uracil...