- Search results for Cay14621
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9 products were found matching "Cay14621"!
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Item number: Cay14621-1
The histone H3 lysine 27 (H3K27) methyltransferase EZH2 plays an important role in regulating gene expression, and its aberrant activity is linked to the onset and progression of cancer. UNC1999 is a cell-permeable EZH2 inhibitor (IC50 = 2 nM) that is 22-fold selective over EZH1 and >1,000-fold selective over other...
Keywords: | N-[(1,2-dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-1H-... |
Application: | Cell-permeable EZH2 inhibitor |
CAS | 1431612-23-5 |
MW: | 569.8 D |
From 43.00€
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Item number: Cay14462-1
Z-FA-FMK is an irreversible inhibitor of cysteine proteases, including cathepsins B, L, and S, cruzain, and papain. It also inhibits effector caspases-2, -3, -6, and -7 (IC50 = 6-32 µM) without affecting the initiator caspases-8 and -10. Z-FA-FMK also modulates infection by certain bacteria, parasites, and viruses....
Keywords: | Z-Phe-Ala-Fluoromethyl Ketone, N-[(1S)-2-[(3-fluoro-1-methyl-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-carbamic... |
Application: | Cysteine protease inhibitor |
CAS | 197855-65-5 |
MW: | 386.4 D |
From 98.00€
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Item number: Cay14623-1
SF7-AM is a cell-trappable fluorogenic probe for the detection of hydrogen sulfide (H2S). Following entry into cells, cleavage of the acetoxymethyl ester groups by intracellular esterases results in an anionic charge, trapping the probe inside the cells. Reaction of the azide moieties with H2S in buffers or live...
Keywords: | Sulfidefluor-7 acetoxymethyl ester,... |
Application: | H2S fluorescent probe |
CAS | 1416872-50-8 |
MW: | 685.6 D |
308.00€
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Item number: Cay14624-1
Isocitrate dehydrogenases (IDHs) are nicotinamide adenine dinucleotide (NAD+) and NAD phosphate (NADP+)-dependent enzymes in the tricarboxylic acid cycle that catalyze oxidative decarboxylation of isocitrate producing a-ketoglutarate (2-OG) and carbon dioxide. IDH1 and IDH2 are mutated in >70% of lower grade...
Keywords: | N-[2-(cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1H-imidazole-1-acetamide |
Application: | Inhibitor of IDH1 R132H and R132C mutants |
CAS | 1355326-35-0 |
MW: | 462.6 D |
From 125.00€
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Item number: Cay14627-1
gamma-Secretase is a multi-subunit aspartyl protease that cleaves amyloid precursor protein (APP) and many other type 1 transmembrane proteins, including Notch, E-cadherin, and ErbB4. The proteolysis of APP by secretases produces beta amyloid (Abeta), a 39- to 42-amino acid peptide which forms the amyloid plaques...
Keywords: | YO-01027, Dibenzazepine,... |
Application: | gamma-secretase inhibitor |
CAS | 209984-56-5 |
MW: | 463.5 D |
From 43.00€
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Item number: Cay14625-1
Physical exertion and exercise are the primary defenses against obesity, insulin resistance, and diabetes. The transcriptional co-activator peroxisome proliferator-activated receptor C coactivator 1alpha (PGC-1alpha), regulates mitochondrial biogenesis and function. Expression of the membrane protein fibronectin...
Keywords: | Anti-FNDC5, Anti-FRCP2, Anti-Irisin, Anti-Fibronectin type III domain-containing protein 5, Anti-Fibronectin type III... |
Application: | ELISA, WB |
Host: | Rabbit |
564.00€
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Item number: Cay14626-1
CMPDA is a positive allosteric modulator of the ionotropic glutamate receptor GluA2. It increases glutamate-induced calcium influx into HEK293 cells expressing human GluA2i or GluA2o receptors (EC50s = 45.4 and 63.4 nM, respectively). CMPDA (10 µM) inhibits desensitization of rat GluA2o and GluA2i receptors, as well...
Keywords: | N,N'-(1,4-phenylenedi-2,1-ethanediyl)bis-2-propanesulfonamide |
Application: | GluR2 positive allosteric modulator |
CAS | 380607-77-2 |
MW: | 376.5 D |
From 50.00€
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Item number: Cay14629-1
Citicoline is an endogenous intermediate in the synthesis of phosphatidylcholine, the major phospholipid in eukaryotic cells. It also serves as a choline donor in the biosynthesis of the neurotransmitter acetylcholine. Citicholine demonstrates protective effects in cerebral ischemia, traumatic brain injury, and...
Keywords: | Cytidine 5'-diphosphocholine, Flussorex, Gerolin, Logan, Neurotron, Sinkron, P'-[2-(trimethylammonio)ethyl] ester-cytidine... |
Application: | Phosphatidylcholine synthesis intermediate, CHPT1 substrate |
CAS | 33818-15-4 |
MW: | 510.3 D |
From 43.00€
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Item number: Cay14682-1
D-Luciferin is a chemiluminescent substrate of firefly luciferase. It produces light upon oxidative decarboxylation by luciferase in the presence of ATP. D-luciferin can be employed to assay the expression of the luciferase gene linked to a promoter of interest. Alternatively, D-luciferin and luciferase can be used...
Keywords: | 4,5-dihydro-2-(6-hydroxy-2-benzothiazolyl)-4S-thiazolecarboxylic acid, monosodium salt |
Application: | Chemiluminescent firefly luciferase substrate |
CAS | 103404-75-7 |
MW: | 302.3 D |
From 50.00€
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